109365-01-7

Upstream product

• 5673-07-4 2,6-dimethoxytoluene 

Downstream Products

• 73233-86-0 2,4-Dimethoxy-3-methylanilin 
• 180147-17-5 2,6-dimethoxy-3-nitrobenzyl bromide 
• 38226-14-1 3-methoxy-2-methyl-6-nitrophenol 
• 929620-20-2 2-benzyloxy-6-bromo-4-methoxy-3-methylaniline 
• 929620-21-3 C₁₅H₁₅NO₄ 
• 116159-71-8 5,7-Dimethoxy-6-methyl-2-[3-(toluene-4-sulfonyloxy)-propyl]-1H-indole-3-carboxylic acid ethyl ester 
• 116138-02-4 1-(2,4-Dimethoxy-3-methyl-phenyl)-5-(3-triisopropylsilanyloxy-propyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester 
• 116138-00-2 1-Azido-2,4-dimethoxy-3-methyl-benzene 
• 3567-46-2 7-methoxymitosene 
• 74364-10-6 6-chloro-3-methoxy-2-methyl-1-phenyl-9H-carbazole 
• 74364-11-7 3-methoxy-2-methyl-1-phenyl-9H-carbazole 

Relevant academic research and scientific papers

Efficient and green telescoped process to 2-methoxy-3-methyl-[1,4] benzoquinone

A telescoped process for the preparation of 2-methoxy-3-methyl-[1,4] benzoquinone is disclosed. When this novel process is compared to the prevailing method that utilizes Na2Cr2O7 as the oxidant, the novel process represen

Enantioselective Synthesis of (+)-Mitomycin K by a Palladium-Catalyzed Oxidative Tandem Cyclization

The mitomycins, a family of bioactive natural products, feature a compact 6/5/5-fused polycyclic ring structure densely decorated with highly reactive and/or fragile quinone, amino ketal, and aziridine as well as carbamate moieties. It is this striking feature that has defeated numerous synthetic attempts towards these apparently small molecules, rendering them one of the most formidable targets for total synthesis. We herein report the first enantioselective synthesis of (+)-mitomycin K, a representative of G series mitomycins. The key step of this synthesis is an enantioselective oxidative cyclization catalyzed by a palladium/(+)-sparteine system that had previously been developed by our group. The robustness of this method bodes well for further applications in the asymmetric total synthesis of natural products, particularly those with characteristic 6/5/5-fused pyrroloindole skeletons.

First total synthesis of the whole series of the antiostatins A and B

The first synthesis of the whole antiostatin family is described by using an iron-mediated carbazole synthesis, regioselective nitration at C-4 and establishing 5-isobutyl-1-nitrobiuret as a reagent for introduction of the antiostatin B side chain at C-4.

Transition metal complexes in organic synthesis, part 74: Total synthesis of the marine alkaloid 6-chlorohyellazole

A considerably improved iron-mediated synthesis leads to the marine carbazole alkaloid hyellazole on large scale in eight steps and 63% overall yield from 2,6-dimethoxytoluene. The first conversion of hyellazole into 6-chlorohyellazole has been achieved a

Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists

Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of liver cirrhosis or Alzheimer''s disease. This application describes such compounds, as well as processes for their preparation and use. The compounds according to this invention include compounds of formula (I) STR1in which B, D, R 1, and R 2 have the meanings indicated herein.

Novel series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B2 receptors

The synthesis and the SAR study of novel O-substituted 8-quinolines and 4-benzothiazoles as highly potent non-peptide bradykinin B2 receptor antagonists are described. Several members of this series of antagonists efficiently inhibited the BK-induced vasoconstriction on different isolated organ preparations.