3567-46-2Relevant academic research and scientific papers
Efficient Synthesis of 7-Methoxymitosene from 6-Methylindole
Nakatsuka, Shin-ichi,Asano, Osamu,Goto, Toshio
, p. 1225 - 1228 (1987)
An effficient synthesis of 7-methoxymitosene from easly available 6-methylindole was achieved by 17 step in 3.0percent overall yield.
SYNTHETIC STUDIES ON MITOMYCIN I. SYNTHESIS OF 7-METHOXYMITOSENE FROM 6-METHYLINDOLE BY SELECTIVE OXIDATION OF BENZENE PART
Asano, Osamu,Nakatsuka, Shin-ichi,Goto, Toshio
, p. 1207 - 1210 (2007/10/02)
Synthesis of 7-methoxymitosene 3, one of the mitosene analog containing common carbon skeleton in mitomycin series was achieved in 19 steps from 6-methylindole 4 by oxidative functionalization methods.
Expeditious Synthesis of 2,3-Dihydro-1H-pyrroloindoles, Pyrroloindole Quinones, and Related Heterocycles via Nenitzescu-Type Condensation of Quinone Monoketals with Exocyclic Enamino Esters
Coates, Robert M.,MacMann, Patrick A.
, p. 4822 - 4824 (2007/10/02)
Condensation of exocyclic enamino esters with 3-methoxyquinone 4-monoketals gives rise to bicyclic Michael adducts (see Table I) which undergo acid-catalyzed aromatization to 5-methoxypyrroloindole-9-carboxylates suitable for elaboration to mitosenes.
Synthesis and Antineoplastic Activity of Mitosene Analogues of the Mitomycins
Hodges, John C.,Remers, William A.,Bradner, William T.
, p. 1184 - 1191 (2007/10/02)
A series of 1-substituted mitosene analogues of the mitomycin antitumor antibiotics was prepared by total synthesis and screened for activity against P388 leukemia in mice.In general, analogues with moderately good leaving groups (mostly esters) at the 1
