1093677-50-9

Basic information

• Product Name: (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(9-fluorenylmethoxycarbonyl)ornithinamide
• Synonyms: (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(9-fluorenylmethoxycarbonyl)ornithinamide
• CAS NO: 1093677-50-9
• Molecular Weight: 649.787
• Mol File: 1093677-50-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(9-fluorenylmethoxycarbonyl)ornithinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(9-fluorenylmethoxycarbonyl)ornithinamide(1093677-50-9)
• EPA Substance Registry System: (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(9-fluorenylmethoxycarbonyl)ornithinamide(1093677-50-9)

Safety Data

• Hazardous Substances Data: 1093677-50-9(Hazardous Substances Data)

Upstream product

• 952729-12-3 (R)-Nδ-benzyloxycarbonyl-Nα-(9-fluorenylmethoxycarbonyl)ornithine 
• 84697-13-2 (4-(tert-butoxy)phenyl)methanamine 

Downstream Products

• 1093677-51-0 (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)ornithinamide 

Relevant articles and documents

Guanidine-acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled NG-propionylargininamide ([3H]-UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist

Synthesis and characterization of (R)-Nα-(2,2- diphenylacetyl)-N-(4-hydroxybenzyl)-Nω-([2,3- 3H]-propanoyl)-argininamide ([3H]-UR-MK114), an easily accessible tritium-labeled NPY Y1 receptor (Y1R) antagonist (KB: 0.8 nM, calcium assay, HEL cells) derived from the (R)-argininamide BIBP 3226, is reported. The radioligand binds with high affinity (KD, saturation: 1.2 nM, kinetic experiments: 1.1 nM, SK-N-MC cells) and selectivity for Y1R over Y2, Y 4, and Y5 receptors. The title compound is a useful pharmacological tool for the determination of Y1R ligand affinities, quantification of Y1R binding sites, and autoradiography.