1093750-99-2

Usage

Uses

Used in Organic Synthesis:
Methyl 6,6-difluorobicyclo[3.1.0]hexane-3-carboxylate serves as a valuable building block in the synthesis of complex organic molecules. Its unique structure allows for the creation of a variety of compounds with potential applications across different industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, methyl 6,6-difluorobicyclo[3.1.0]hexane-3-carboxylate is utilized as a key intermediate in the development of pharmaceuticals. Its distinctive fluorinated cyclopropane ring can contribute to the design of novel drugs with improved properties, such as enhanced potency, selectivity, and bioavailability.
Used in Drug Discovery and Development:
Researchers in drug discovery and development find methyl 6,6-difluorobicyclo[3.1.0]hexane-3-carboxylate to be a valuable tool. Its incorporation into the molecular structures of potential drugs can lead to the discovery of new therapeutic agents with unique mechanisms of action and the potential to treat a wide range of diseases and conditions.

Upstream product

• 58101-60-3 methyl cyclopent-3-ene-1-carboxylate 
• 70395-35-6 sodium chlorofluoroacetate 
• 1895-39-2 sodium chlorodifluoroacetate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 1093751-02-0 6,6-difluorobicyclo[3.1.0]hexane-3-carboxylic acid 
• 1447942-40-6 (1R,3S,5S)-6,6-difluorobicyclo[3.1.0]hexane-3-carboxylic acid 
• 1447942-40-6 cis-6,6-difluorobicyclo[3.1.0]hexane-3-carboxylic acid 
• 1093751-05-3 cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery

Difluorocyclopropane-containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF3/NaI. Novel fluorinated acids, amines, amino acids, alcohols, ketones and sulfonyl chlorides were obtained.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES

Substituted aryl pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

SUBSTITUTED ARYL PYRIMIDINONES

Substituted aryl pyrimidinones are provided, of the Formula (I) wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

SUBSTITUTED PYRIMIDINONES

Substituted pyrimidinones are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.