109376-35-4 Usage
Uses
(Ethoxycarbonylmethyl)triphenylphosphonium-13C2 bromide is an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope labelled Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.
Check Digit Verification of cas no
The CAS Registry Mumber 109376-35-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,3,7 and 6 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 109376-35:
(8*1)+(7*0)+(6*9)+(5*3)+(4*7)+(3*6)+(2*3)+(1*5)=134
134 % 10 = 4
So 109376-35-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H22O2P.BrH/c1-2-24-22(23)18-25(19-12-6-3-7-13-19,20-14-8-4-9-15-20)21-16-10-5-11-17-21;/h3-17H,2,18H2,1H3;1H/q+1;/i18+1,22+1;
109376-35-4Relevant articles and documents
Synthesis of the lipid peroxidation product 4-hydroxy-2(E)-nonenal with 13C stable isotope incorporation
Jouanin,Sreevani,Rathahao,Gueraud,Paris
, p. 87 - 92 (2008)
The aim of this work was to synthesize 13C internal standards for the quantification of 4-hydroxy-2(E)-nonenal (HNE), a lipid peroxidation product, and of the etheno-adducts possibly formed by HNE damage to DNA nucleobases. We designed an eight-step synthesis starting from ethyl 2-bromoacetate and giving access to 4-[(tetrahydro-2H-pyran-2-yl)oxy]-2(E)- nonenal. This compound is a precursor of HNE. The scheme was then used to produce the 13C precursor [1,2-13C2]-4- [(tetrahydro-2H-pyran-2-yl)oxy]-2(E)-nonenal. [1,2-13C 2]HNE was obtained by acid deprotection. All the intermediary and final compounds were fully characterized by IR, HRMS, 1H and 13C NMR. It is the first synthesis of HNE which enables the incorporation of two 13C labels at determined positions. Copyright
