109376-35-4 Usage
Uses
Used in Chemical Synthesis:
(CARBETHOXYMETHYL-1,2-13C2)TRIPHENYLPHOSPHONIUM BROMIDE is used as an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope-labeled version of Mutagen X (MX). (CARBETHOXYMETHYL-1,2-13C2)TRIPHENYLPHOSPHONIUM BROMIDE is a chlorinated furanone that is responsible for a significant portion of the mutagenic activity found in drinking water as a result of disinfection processes.
Used in Environmental Chemistry and Toxicology:
In the field of environmental chemistry and toxicology, (CARBETHOXYMETHYL-1,2-13C2)TRIPHENYLPHOSPHONIUM BROMIDE is used as a precursor for the production of isotope-labeled MX. This allows researchers to study the effects of MX on DNA and its role in the mutagenic activity of drinking water. The isotope labeling also enables the investigation of the repair mechanisms of DNA damages provoked by various mutagens, such as furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan, which are subject to the nucleotide excision repair system.
Used in Pharmaceutical Research:
(CARBETHOXYMETHYL-1,2-13C2)TRIPHENYLPHOSPHONIUM BROMIDE can also be utilized in pharmaceutical research as a starting material for the synthesis of isotopically labeled compounds that can be used as tracers or markers in the study of drug metabolism, pharmacokinetics, and drug-drug interactions. The incorporation of carbon-13 isotopes in the molecule allows for the detection and analysis of these compounds using techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.
Check Digit Verification of cas no
The CAS Registry Mumber 109376-35-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,3,7 and 6 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 109376-35:
(8*1)+(7*0)+(6*9)+(5*3)+(4*7)+(3*6)+(2*3)+(1*5)=134
134 % 10 = 4
So 109376-35-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H22O2P.BrH/c1-2-24-22(23)18-25(19-12-6-3-7-13-19,20-14-8-4-9-15-20)21-16-10-5-11-17-21;/h3-17H,2,18H2,1H3;1H/q+1;/i18+1,22+1;
109376-35-4Relevant academic research and scientific papers
Jouanin,Sreevani,Rathahao,Gueraud,Paris
, p. 87 - 92 (2008)
The aim of this work was to synthesize 13C internal standards for the quantification of 4-hydroxy-2(E)-nonenal (HNE), a lipid peroxidation product, and of the etheno-adducts possibly formed by HNE damage to DNA nucleobases. We designed an eight-step synthesis starting from ethyl 2-bromoacetate and giving access to 4-[(tetrahydro-2H-pyran-2-yl)oxy]-2(E)- nonenal. This compound is a precursor of HNE. The scheme was then used to produce the 13C precursor [1,2-13C2]-4- [(tetrahydro-2H-pyran-2-yl)oxy]-2(E)-nonenal. [1,2-13C 2]HNE was obtained by acid deprotection. All the intermediary and final compounds were fully characterized by IR, HRMS, 1H and 13C NMR. It is the first synthesis of HNE which enables the incorporation of two 13C labels at determined positions. Copyright
