61898-49-5

Usage

Uses

Used in Synthesis of 13C4-Labeled Metabolites:
ETHYL BROMOACETATE-13C2 is used as a reactant in the synthesis of 13C4-labeled metabolites of carcinogenic polycyclic aromatic hydrocarbons (PAHs). This application is important for studying the metabolism and toxicology of these harmful compounds.
Used in Pharmaceutical Industry:
ETHYL BROMOACETATE-13C2 is used as a reactant in the preparation of steroidal antiestrogens through cyclic condensation. This application is crucial for the development of pharmaceuticals that can help in the treatment of hormone-dependent conditions.
Used in Antimicrobial and Antioxidant Compounds Synthesis:
ETHYL BROMOACETATE-13C2 is used as a reactant in the preparation of coumarinyloxymethyl-thiadiazolone, which has antimicrobial and antioxidant properties. This application is significant in the development of new compounds for use in medicine and other industries.

InChI:InChI=1/C4H7BrO2/c1-2-7-4(6)3-5/h2-3H2,1H3/i3+1,4+1

Upstream product

• 16651-47-1 [1,2-13C₂]acetic acid 
• 64-17-5 ethanol 
• 52947-00-9 bromo[1,2-¹³C₂]acetic acid 

Downstream Products

• 326794-15-4 C₉⁽¹³⁾C₂H₉⁽²⁾H₅O₃ 
• 90830-64-1 (ethoxycarbonyl<13C>methyliden)triphenylphosphorane 
• 109376-35-4 (ethoxycarbonyl<13C>methyl)triphenylphosphonium bromide 
• 1310742-32-5 C₉⁽¹³⁾C₂H₁₄O₄ 
• 100940-60-1 [¹³C₂]-triethyl phosphonoacetate 
• 944385-48-2 ethyl 2-(4-methoxy phenyl)[1,2-¹³C₂]acetate 

Relevant academic research and scientific papers

Synthesis of 5-[4,5-13C2]- and 5-[1,5-13C2]aminolevulinic acid

5-[4,5-13C2]- and 5-[1,5-13C2]Aminolevulinic acid (ALA) have been synthesized by the Gabriel condensation of potassium phthalimide with ethyl bromo [1,2-13C2]acetate (derived from [1,2-13C2]acetic acid) or ethyl bromo[2-13C]-acetate (derived from sodium [2-13C]acetate), followed by conversion to the chloride, coupling reaction with 2-ethoxycarbonylethylzinc iodide derived from ethyl 3-iodopropionate or 2-methoxy[13C]carbonylethylzinc iodide derived from methyl 3-iodo[1-13C]propionate (generated from potassium [13C]cyanide), and hydrolysis. Copyright

Quantitation of Nine Lactones in Dairy Cream by Stable Isotope Dilution Assays Based on Novel Syntheses of Carbon-13-Labeled γ-Lactones and Deuterium-Labeled δ-Lactones in Combination with Comprehensive Two-Dimensional Gas Chromatography with Time-of-Flight Mass Spectrometry

Lactones are well-known aroma compounds in, e.g., fruits and fermented foods as well as in dairy products, such as cream or milk powders. The latter are often used in confectionary products, e.g., milk chocolate. Lactones are suggested to contribute to the distinct aroma of dairy products and have also been reported in milk chocolate. However, data on their contribution to the overall aroma of this type of chocolate are scarce. As a result of their pH-dependent instability and their low volatility, a reliable quantitation of lactones is a challenge. Thus, to allow for a quantitation of nine lactones in one single comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry in electron ionization mode run, new synthetic routes were developed for five carbon-13-labeled γ-lactones and four deuterium-labeled δ-lactones, with the isotope label in the ring to be used in stable isotope dilution assays. The concentrations of the nine lactones were then analyzed in raw and pasteurized cream as well as in a heat-treated raw cream. δ-Dodecalactone and δ-decalactone showed the highest concentrations in both the raw and pasteurized cream. In the latter, δ-dodecalactone reached a 2.5-fold higher concentration compared to the raw cream. Subsequent heat treatments in a lab scale showed a further increase by factors of 13 and 19, respectively, suggesting a high potential of lactone precursors in cream. The results serve as a basis for further studies on lactone formation in other thermally processed products, such as milk chocolate.

The preparation of all-trans uniformly 13C-labeled retinal via a modular total organic synthetic strategy. Emerging central contribution of organic synthesis toward the structure and function study with atomic resolution in protein research

Uniformly [13C20]-labeled all-trans-retinal (1) has been prepared via a convergent modular total organic strategy with high isotope incorporation (>99%) and without isotope dilution starting from commercially available 99% enriched