1093863-59-2Relevant academic research and scientific papers
Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity
Okitsu, Takashi,Sato, Kana,Iwatsuka, Kinya,Sawada, Natsumi,Nakagawa, Kimie,Okano, Toshio,Yamada, Shoya,Kakuta, Hiroki,Wada, Akimori
experimental part, p. 2939 - 2949 (2011/06/21)
Retinoid X receptor (RXR) agonists are interesting candidates for the treatment of metabolic syndrome. 9-Cis-retinoic acid (9cRA: 1) is a natural RXR agonist, that also works as a retinoic acid receptor (RAR) agonist. This fact prompted us to study the st
New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists
Alvarez, Susana,Pazos-Randulfe, Yolanda,Khanwalkar, Harshal,Germain, Pierre,Alvarez, Rosana,Gronemeyer, Hinrich,de Lera, Angel R.
experimental part, p. 9719 - 9728 (2009/04/06)
A series of 9-cis-retinoic acid analogs modified at the hydrophobic ring with a (bi)cyclohexenyl moiety derived from natural terpenes has been stereoselectively prepared using a Suzuki cross-coupling as key step. Transient transactivation studies indicate
