1093975-68-8Relevant articles and documents
Triazoles as γ-secretase modulators
Fischer, Christian,Zultanski, Susan L.,Zhou, Hua,Methot, Joey L.,Brown, W. Colby,Mampreian, Dawn M.,Schell, Adam J.,Shah, Sanjiv,Nuthall, Hugh,Hughes, Bethany L.,Smotrov, Nadja,Kenific, Candia M.,Cruz, Jonathan C.,Walker, Deborah,Bouthillette, Melanie,Nikov, George N.,Savage, Dan F.,Jeliazkova-Mecheva, Valentina V.,Diaz, Damaris,Szewczak, Alexander A.,Bays, Nathan,Middleton, Richard E.,Munoz, Benito,Shearman, Mark S.
, p. 4083 - 4087 (2011/08/02)
Synthesis, SAR, and evaluation of aryl triazoles as novel gamma secretase modulators (GSMs) are presented in this communication. Starting from the literature and in-house leads, we evaluated a range of five-membered heterocycles as replacements for olefin
TRIAZOLE DERIVATIVES FOR TREATING ALZHEIMER'S DISEASE AND RELATED CONDITIONS
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Page/Page column 36-37; 45; 47, (2009/01/23)
Compounds of formula I: Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain, in particular Alzheimer's disease.