1094-76-4

Basic information

• Product Name: epsilon-dinitrophenyllysine
• Synonyms: epsilon-dinitrophenyllysine
• CAS NO: 1094-76-4
• Molecular Formula: C₁₂H₁₆N₄O₆
• Molecular Weight: 312.2786
• Mol File: 1094-76-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 571.6°Cat760mmHg
• Flash Point: 299.5°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 6.6E-14mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: epsilon-dinitrophenyllysine(CAS DataBase Reference)
• NIST Chemistry Reference: epsilon-dinitrophenyllysine(1094-76-4)
• EPA Substance Registry System: epsilon-dinitrophenyllysine(1094-76-4)

Safety Data

• Hazardous Substances Data: 1094-76-4(Hazardous Substances Data)

Usage

Definition

ChEBI: The L-stereoisomer of N6-(2,4-dinitrophenyl)lysine, a lysine derivative having a 2,4-dinitrophenyl substituent at the N6-position.

InChI:InChI=1/C12H16N4O6/c13-9(12(17)18)3-1-2-6-14-10-5-4-8(15(19)20)7-11(10)16(21)22/h4-5,7,9,14H,1-3,6,13H2,(H,17,18)/t9-/m0/s1

Upstream product

• 1202639-03-9 C₂₁H₂₄N₄O₁₀S 
• 1202639-01-7 C₂₂H₂₆N₄O₁₀S 
• 1346693-90-0 C₃₆H₄₁N₅O₁₁S 
• 1346693-89-7 C₃₄H₃₇N₅O₁₂S 
• 1346693-88-6 C₃₄H₃₇N₅O₁₁S 
• 1346693-87-5 C₃₅H₃₉N₅O₁₁S 
• 1346693-86-4 C₃₃H₃₅N₅O₁₁S 
• 1346693-85-3 C₃₃H₃₄ClN₅O₁₁S 
• 1202639-17-5 C₂₃H₂₄N₆O₁₀ 
• 1202638-76-3 C₁₄H₁₅NO₇S 
• 14401-10-6 Nε-2,4-dinitrophenyl-L-lysine hydrochloride 
• 1202639-20-0 C₃₃H₂₉BrN₄O₈ 
• 1202639-19-7 C₂₈H₂₈N₄O₈ 
• 1202639-16-4 C₂₄H₂₇N₅O₉ 

Downstream Products

• 929540-21-6 C₄₆H₆₃N₅O₁₇ 

Relevant articles and documents

A peptide-based fluorescent probe images ERAAP activity in cells and in high throughput assays

ERAAP is an intracellular amino-peptidase that plays a central role in determining the repertoire of peptides displayed by cells by MHC class I molecules, and dysfunctions in ERAAP are linked to a variety of diseases. There is therefore great interest in developing probes that can image ERAAP in cells. In this report we present a fluorescent probe, termed Ep, that can image ERAAP activity in live cells. Ep is composed of a 10 amino acid ERAAP substrate that has a donor quencher pair conjugated to it, composed of BODIPY and dinitro-toluene. Ep undergoes a 20-fold increase in fluorescence after ERAAP cleavage, and was able to image ERAAP activity in cell culture via fluorescence microscopy. In addition, we used Ep to develop a high throughput screen for ERAAP inhibitors, and screened an electrophile library containing 1460 compounds. From this Ep based screen we identified aromatic alkyne-ketone as a lead fragment that can irreversibly inhibit ERAAP activity. We anticipate numerous applications of Ep given its unique ability to image ERAAP within cells.

CONTROLLED RELEASE FROM MACROMOLECULAR CONJUGATES

The invention relates to conjugates of macromolecular carriers and drugs comprising linkers that release the drug or a prodrug through rate-controlled beta-elimination, and methods of making and using the conjugates.

Synthesis and application of unprotected cyclic peptides as building blocks for peptide dendrimers

We describe an efficient regiospecific method for cyclization of unprotected peptide segments based on intramolecular transthioesterification of unprotected cysteinyl peptide thioesters under the control of ring-chain tautomeric equilibrium in aqueous buf