1094019-47-2

Basic information

• Product Name: 3-(4-fluorophenyl)isoquinoline-1(2H)-one
• Synonyms: 3-(4-fluorophenyl)isoquinoline-1(2H)-one
• CAS NO: 1094019-47-2
• Molecular Weight: 239.249
• Mol File: 1094019-47-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-(4-fluorophenyl)isoquinoline-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)isoquinoline-1(2H)-one(1094019-47-2)
• EPA Substance Registry System: 3-(4-fluorophenyl)isoquinoline-1(2H)-one(1094019-47-2)

Safety Data

• Hazardous Substances Data: 1094019-47-2(Hazardous Substances Data)

Upstream product

• 5597-04-6 2-cyanomethylbenzoic acid methyl ester 
• 2042-37-7 o-cyanobromobenzene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 3930-83-4 o-iodobenzamide 
• 4001-73-4 2-Bromobenzamide 
• 1260150-34-2 1-ethoxy-3-(4-fluorophenyl)isoquinoline 
• 135030-39-6 3-(4-fluorophenyl)-1H-2-benzopyran-1-one 
• 1765-93-1 4-fluoroboronic acid 

Relevant articles and documents

Isoquinolone synthesis through SNAr reaction of 2-halobenzonitriles with ketones followed by cyclization

An efficient method for the synthesis of isoquinolones through base KOtBu-promoted SNAr reaction of 2-halobenzonitriles with ketones followed by Lewis acid Cu(OAc)2-catalyzed cyclization is described. Isoquinolone derivati

Method for synthesizing anti-cancer inhibitor intermediate

The invention relates to a method for synthesizing an isoquinolone derivative of formula (III) as an anti-cancer inhibitor intermediate. The method comprises the step: in a reaction solvent, in the presence of a catalyst, a nitrogen-containing ligand, an acid additive and 4-dimehtyl aminopyridine, performing a reaction on a compound of formula (I) as shown in the specification and a compound of formula (II) as shown in the specification, and after posttreatment, obtaining a compound of formula (III) as shown in the specification, wherein in the formulae, R1 is C1-C6 alkyl; R2 is H, halogen, C1-C6 alkyl or C1-C6 alkoxy; or R2 and substituted phenyl form naphthyl; and M is an alkali metal element. By adopting the method, due to comprehensive selection and mutual action of a reaction substrate, the catalyst, the nitrogen-containing ligand, the acid additive, the 4-dimehtyl aminopyridine and the solvent, the substrate range can be widened, a target product of high yield can be obtained, an intermediate of relatively rich diversities can be provided for synthesis of the compounds and development and synthesis of anti-cancer inhibitor medicines, and good research values and application potential can be achieved.

Tandem addition/cyclization for access to isoquinolines and isoquinolones via catalytic carbopalladation of nitriles

The first example of the palladium-catalyzed sequential nucleophilic addition followed by an intramolecular cyclization of functionalized nitriles with arylboronic acids has been achieved, providing an efficient synthetic pathway to access structurally di