109417-60-9

Usage

Physical state

Colorless to pale yellow liquid

Odor

Strong

Usage

Production of pharmaceuticals, fragrances, intermediate in organic synthesis, production of herbicides and insecticides

Potential medical application

Treatment of cardiovascular and endocrine disorders

Precaution

Handle with caution due to potential health hazards and environmental impact

Upstream product

• 41532-81-4 2-methoxyethyl phenyl ether 
• 95-56-7 2-hydroxybromobenzene 
• 6482-24-2 2-Bromoethyl methyl ether 
• 109-86-4 2-methoxy-ethanol 
• 627-42-9 2-chloroethyl methyl ether 

Downstream Products

• 109417-61-0 (S)-(-)-o-(2-methoxyethoxy)phenyl p-tolyl sulfoxide 
• 109417-63-2 (S)-(-)-S-o-(2-methoxyethoxy)phenyl-S-p-tolylsulfoximine 
• 109417-64-3 (S)-(+)-N-ethoxycarbonylmethyl-S-o-(2-methoxyethoxy)phenyl-S-p-tolylsulfoximine 
• 1122568-09-5 [2-(2-methoxyethoxy)phenyl]boronic acid 
• 1079402-28-0 2-[2-(2-methoxyethoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]-dioxaborolane 

Relevant academic research and scientific papers

FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF

Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.

AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS

The present invention relates to novel aminoindazolyl derivative compounds of Formula(I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.

Identification of a new biaryl scaffold generating potent renin inhibitors

The discovery and SAR of a series of potent renin inhibitors possessing a novel biaryl scaffold are described herein. Molecular modeling revealed that the cyclopropylamide spacer present in 1 can be replaced by a simple, substituted aromatic ring such as

SELECTIV BROMINATION OF THE AROMATIC RING IN ω-PHENYLPOLYOXAALKANES AND ALKANOLS IN MICELLES

The regioselecticity of bromination of ω-phenylpolyoxaalkanes and alkanols by bromine in aqueous solution of dodecyl sulfate (SDS) and aqueous solution of cetyltrimethylammonium bromide (CTAB) are shown to be related to the average orientation of substrate as indicated by 1H NMR studies.Thus ortho-bromination is promoted at higher concentrations of the surfactant relative to pure water.In contrast, at an equal ratio of the surfactant and substrate para-bromination is promoted.The results are discussed with respect to the average orientation of substrate in a micellar microenvironment and the formation of an ether-bromine comples as possible bromination agent.

Chiral Induction in the Methylation of N-Ethoxycarbonylmethyl Sulfoximines

Chiral inductions in the C-methylations of four optically active N-ethoxycarbonylmethyl-S-p-tolylsulfoximines were explored by using the reagents lithium diisopropylamide (in tetrahydrofuran at -78 deg) then methyl iodide.When the fourth substituent at su