1094332-66-7

Basic information

• Product Name: N-Cyclohexyl 4-chloropicolinaMide
• Synonyms: N-Cyclohexyl 4-chloropicolinaMide;4-chloro-N-cyclohexylpyridine-2-carboxamide
• CAS NO: 1094332-66-7
• Molecular Formula: C₁₂H₁₅ClN₂O
• Molecular Weight: 238.7133
• Mol File: 1094332-66-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Cyclohexyl 4-chloropicolinaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cyclohexyl 4-chloropicolinaMide(1094332-66-7)
• EPA Substance Registry System: N-Cyclohexyl 4-chloropicolinaMide(1094332-66-7)

Safety Data

• Hazardous Substances Data: 1094332-66-7(Hazardous Substances Data)

Upstream product

• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 108-91-8 cyclohexylamine 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 51727-15-2 4-chloro-2-pyridine carboxylic acid chloride hydrochloride 
• 98-98-6 2-Picolinic acid 

Downstream Products

• 1412891-70-3 4-(3-aminophenoxy)-N-cyclohexylpicolinamide 
• 1412891-47-4 4-(3-(3-(3,4-difluorophenyl)thioureido)phenoxy)-N-ethylpicolinamide 
• 1412891-52-1 N-cyclohexyl-4-(3-(3-(3-(trifluoromethyl)phenyl)thioureido)phenoxy)picolinamide 
• 1412891-58-7 4-(3-(3-(4-chloro-3-(trifluoromethyl)phenyl)thioureido)phenoxy)-N-cyclohexylpicolinamide 
• 1417344-67-2 4-(4-aminophenylthio)-N-cyclohexylpicolinamide 
• 1395063-35-0 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)thioureido)phenylthio)-N-cyclohexylpicolinamide 
• 1395063-34-9 N-cyclohexyl-4-(4-(3-(3-(trifluoromethyl)phenyl)thioureido)phenylthio)picolinamide 
• 1395063-36-1 N-cyclohexyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenylthio)picolinamide 
• 1395063-37-2 4-(4-(3-(4-chlorophenyl)thioureido)phenylthio)-N-cyclohexylpicolinamide 

Relevant articles and documents

Styryl pyridine compound containing pyridine structure, preparation method and application of styryl pyridine compound in preparation of antitumor drugs (by machine translation)

The invention belongs to the field, and particularly relates to a styryl pyridine compound containing a pyridine structure, a preparation method and an application of the styryl pyridine compound in preparation of anti-tumor drugs, wherein the compound is a compound as shown in the formula I. The compound of the general formula I has good inhibitory activity on non-small cell lung cancer A549 and liver cancer cell HepepepG2, can be used for preparing antitumor drugs, and is especially suitable for cancers, kidney cancer, lung cancer, thyroid cancer, colon cancer and other tumors. (by machine translation)

The structure of the amine-containing thiourea compound and its preparation method and application

A disclosed thiourea compounds containing an arylamine structure comprises compounds of a general formula I and pharmaceutically acceptable salts. In the general formula I shown in the specification, R1 is selected from H, C1-C8 alkyl, halogens, -CF3, -OCF3, -NO2, -CN, R2O-, -SO2NH2, -NHSO2R3, -NR4R5, -CONR6R7, -COOR8, R9CO- and disubstituted and trisubstituted combinations thereof, R2, R3, R4, R5, R6, R7, R8 and R9 are respectively H or C1-C8 alkyl, L is selected from -NHR10, -NHOR11, -NR12R13, pyrrolidin-1-yl, 4-piperidyl and (4-methyl-1-piperazinyl)methylene, and R10, R11, R12 and R13 are respectively H, C1-C8 alkyl, cycloalkyl or aryl. The compounds have inhibiting effect on multiple tumor cell strains.

Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents

A novel series of diaryl thiourea containing sorafenib derivatives 9a-t was designed and synthesized. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR and HRMS. Their antiproliferative activities against HCT116 and MDA-MB-231 cell lines, and their inhibitory activities against the phosphorylation of VEGFR were evaluated and described. Some of the compounds showed significant activities against both cell lines and VEGFR. Compounds 9g, 9m, 9o and 9p demonstrated competitive antiproliferative activities to sorafenib, the reference standard, while compounds 9d, 9m, and 9p showed significant inhibitory activities against the phosphorylation of VEGFR.