109435-47-4

Upstream product

• 122-78-1 phenylacetaldehyde 
• 613-94-5 benzoic acid hydrazide 

Downstream Products

• 96272-27-4 2-(N'-Benzoyl-N-phenylacetyl-hydrazino)-N-tert-butyl-3-phenyl-propionamide 
• 92437-24-6 2-phenyl-5-(phenylmethyl)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Efficient oxidative cyclization of N -acylhydrazones for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles using t-BuOI under neutral conditions

An efficient procedure for the oxidative cyclization of N -acylhydrazones was developed utilizing tert-butyl hypoiodite (t-BuOI), which is generated in situ from t -BuOCl and NaI. A variety of 2,5-disubstituted 1,3,4-oxadiazoles were synthesized in high yields within short reaction time. The method is also suitable for cyclization of N -acylhydrazones derived from heterocyclic aldehydes and aliphatic aldehydes. Mild reaction conditions and simple workup operations make the procedure a good alternative for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles.