92437-24-6

Basic information

• Product Name: 1,3,4-Oxadiazole, 2-phenyl-5-(phenylmethyl)-
• CAS NO: 92437-24-6
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Mol File: 92437-24-6.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 1,3,4-Oxadiazole, 2-phenyl-5-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Oxadiazole, 2-phenyl-5-(phenylmethyl)-(92437-24-6)
• EPA Substance Registry System: 1,3,4-Oxadiazole, 2-phenyl-5-(phenylmethyl)-(92437-24-6)

Safety Data

• Hazardous Substances Data: 92437-24-6(Hazardous Substances Data)

Upstream product

• 19836-24-9 N-benzoyl-N'-phenylacetyl-hydrazine 
• 103-82-2 phenylacetic acid 
• 613-94-5 benzoic acid hydrazide 
• 98-88-4 benzoyl chloride 
• 1663-61-2 triethoxymethylbenzene 
• 937-39-3 2-phenylacetylhydrazine 
• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 13326-10-8 benzyl methyl carbonate 
• 591-50-4 iodobenzene 
• 119072-55-8 tert-butylisonitrile 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 6125-24-2 2-Phenylnitroethane 
• 101-41-7 benzeneacetic acid methyl ester 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 130781-65-6 3,4-Dibenzyl-5-phenyl-4H-[1,2,4]triazole 
• 130781-64-5 3-Benzyl-4-butyl-5-phenyl-4H-[1,2,4]triazole 

Relevant articles and documents

Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et 2NSF2]BF4 as a practical cyclodehydration agent

The preparation of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using XtalFluor-E ([Et2NSF2]BF4) as cyclodehydration reagent is described. Various functionalized 1,3,4-oxadiazoles were synthesized and it was found that the use of acetic acid as an additive generally improved the yields.

UV-Induced 1,3,4-Oxadiazole Formation from 5-Substituted Tetrazoles and Carboxylic Acids in Flow

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

Study on DDQ-promoted synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles from acid hydrazides and aldehydes

A facile stepwise synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles proceeding via oxidative cyclization of N-acylhydrazones is reported. The reaction is efficiently promoted by 2, 3-dichloro-5, 6-dicyano-1, 4- benzoquinone (DDQ) to afford the desired products mostly in high yields and in relatively short times. The final 1, 3, 4-oxadiazole derivatives are also synthesized directly from acid hydrazides and aldehydes in a one-pot procedure. The substrate scope and limitations of the reported transformation are discussed in detail.