1094496-62-4Relevant articles and documents
High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones
Cholewiak, Agnieszka,Adamczyk, Kamil,Kopyt, Micha?,Kasztelan, Adrian,Kwiatkowski, Piotr
, p. 4365 - 4371 (2018/06/22)
The application of high pressure (up to 9 kbar) allows for relatively fast (1-5 h) and highly enantioselective 1,4-addition of nitromethane and 2-nitropropane to chalcones at room temperature with substantial reduction of catalyst loading (0.2-1 mol% of cinchona alkaloid-based thioureas and squaramides). Various γ-nitroketones were obtained at 9 kbar with high yield and enantioselectivity (up to 98%), whereas in control experiments at atmospheric pressure usually only a small amount (10%) of products were formed after 20 h.
Organocatalyzed highly stereoselective Michael addition of ketones to alkylidene malonates and nitroolefins using chiral primary-secondary diamine catalysts based on bispidine
Liu, Jie,Yang, Zhigang,Liu, Xiaohua,Wang, Zhen,Liu, Yanling,Bai, Sha,Lin, Lili,Feng, Xiaoming
supporting information; experimental part, p. 4120 - 4127 (2009/12/06)
Organocatalysts containing primary-secondary diamines based on bispidine have been developed to catalyze the asymmetric Michael addition of ketones to alkylidene malonates and nitroalkenes. The corresponding products were obtained in high yields (up to 99
