109463-53-8Relevant academic research and scientific papers
ONE POT PREPARATION OF 1,3-DIMETHYLTETRAHYDROISOQUINOLINES FROM THEIR BIOSYNTHETIC DIKETO PRECURSORS
Bringmann, Gerhard,Jansen, Johannes R.
, p. 2407 - 2410 (2007/10/02)
Biomimetic reactions modelling the nitrogen incorporation into the monocyclic precursors 2 of naphthylisoquinoline alkaloids, using pyridoxamine (9b) are described.The condensation of 2b with 9b, or , more simply, with benzylamine, though not giving a dihydroisoquinoline 7 , provides an efficient one pot synthesis of already protected 1,3-dimethyltetrahydroisoquinolines 14, by in situ reduction of the resulting isoquinolinium salts 12.
