1094718-97-4

Basic information

• Product Name: 1-(6-methyl-1H-indol-3-yl)ethanone
• Synonyms: 1-(6-methyl-1H-indol-3-yl)ethanone
• CAS NO: 1094718-97-4
• Molecular Formula: C11H11NO
• Molecular Weight: 173.21
• Mol File: 1094718-97-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(6-methyl-1H-indol-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-methyl-1H-indol-3-yl)ethanone(1094718-97-4)
• EPA Substance Registry System: 1-(6-methyl-1H-indol-3-yl)ethanone(1094718-97-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1094718-97-4(Hazardous Substances Data)

Usage

General Description

1-(6-methyl-1H-indol-3-yl)ethanone, also known as 6-MIE, is a chemical compound with the molecular formula C11H11NO. It is a ketone derivative of indole, a heterocyclic aromatic organic compound. 6-MIE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and fragrance compounds. It has also been identified as a potential environmental pollutant and is known to have an impact on aquatic organisms. Additionally, research has shown that 6-MIE may have some pharmacological properties, including analgesic and anti-inflammatory effects, which makes it a significant molecule of interest for further scientific study.

Upstream product

• 3420-02-8 6-methylindole 
• 1134783-33-7 N-(p-toluenesulfonyl)-3-acetyl-6-methylindole 
• 75-36-5 acetyl chloride 

Downstream Products

• 1134783-33-7 N-(p-toluenesulfonyl)-3-acetyl-6-methylindole 

Relevant articles and documents

Feasible selective synthesis of 3-Acetylindoles and 3-Acetoacetylindoles from β-ethylthio-β-indoly α, β-unsaturated ketones

An efficient and selective synthesis of 3-acetyl free(N-H)/N-substituded indoles and 3-acetoacetyl free(N-H)/N-substituded indoles has been developed via the hydrolysis reaction of β-ethylthio-β-indoly α, β-unsaturated ketones in the presence of 3 equivalent of NaOH and 5 mol% of H2SO4, respectively. The procedure features easy operation, excellent yields, and high selectivity, compatibility and practicability.

Rh(III)-Catalyzed [5 + 1] Annulation of Indole-enaminones with Diazo Compounds to Form Highly Functionalized Carbazoles

A novel Rh(III)-catalyzed C-H activation/annulation cascade of indole-enaminones with diazo compounds was reported to construct diversely functionalized carbazole frameworks. The most notable characteristic is that this transformation could smoothly furnish a novel [5 + 1] cyclization product with good to excellent yields (up to 95%), accompanied by the thorough removal of acetyl and N,N-dimethyl groups of two substrates from the target products, rather than the normally expected [4 + 2] cyclization products.

Rhodium(III)-catalyzed C4-amidation of indole-oximes with dioxazolones: Via C-H activation

A novel method for the Rh(III)-catalyzed oxime-directed C-H amidation of indoles with dioxazolones has been developed. This strategy provides an exclusive site selectivity and the directing group can be easily removed. This transformation features a wide substrate scope, good functional group tolerance and excellent yields, and may serve as a significant tool to construct structurally diverse indole derivatives for the screening of potential pharmaceuticals in the future. This journal is