109472-90-4Relevant articles and documents
Evaluating the reactivity and stereoselectivity of salicyl-type thioglycosides as non-malodorous thioglycoside alternatives for oligosaccharide synthesis
Dohi, Hirofumi,Sakurai, Risa,Tamura, Manami,Komai, Ryota,Nishida, Yoshihiro
, p. 45 - 65 (2021/05/26)
Herein, o-(methoxycarbonyl)phenyl thioglycosides [or (methyl)salicyl 1-thioglycosides] were evaluated as non-malodorous thioglycoside alternatives. The o-methoxycarbonyl group was expected to assist in the departure of leaving group. Salicyl-type thioglyc
Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety
Cui, Zining,Yang, Xinling,Shi, Yanxia,Uzawa, Hirotaka,Cui, Jingrong,Dohi, Hirofumi,Nishida, Yoshihiro
, p. 7193 - 7196 (2012/02/02)
Assuming that the water solubility of our previous hydrazone derivatives would improve after modification with sugars while keeping or modulating their notable biological activities, we designed and synthesized some glycosyl hydrazine and hydrazone derivatives. Bioassay results indicated that the antitumor activity of our previously prepared hydrazones reduced or disappeared after modification with sugars. On the contrary, some glycosyl derivatives displayed much better antifungal activity against selected fungi. Obviously, a small sugar can change the biological activity of hydrazones significantly.
