1095089-35-2Relevant academic research and scientific papers
Biphenomycin B and derivatives: Total synthesis and translation inhibition
He, Yu-Peng,Tan, Hao,Arve, Lars,Baumann, Sascha,Waldmann, Herbert,Arndt, Hans-Dieter
, p. 1546 - 1556 (2013/01/11)
A full account on the synthesis of the antibiotic natural product biphenomycin B and several derivatives is reported, which employs a Suzuki coupling reaction of a free carboxylic acid and macrolactam formation as key transformations. Liberal exchange of
Flexible total synthesis of biphenomycin B
Waldmann, Herbert,He, Yu-Peng,Tan, Hao,Arve, Lars,Arndt, Hans-Dieter
scheme or table, p. 5562 - 5564 (2009/04/13)
A total synthesis of the biaryl antibiotic biphenomycin B is reported which makes use of three independent building blocks (key steps were a clean Suzuki-Miyaura coupling of a free acid iodide, a novel 4-hydroxyornithine synthesis, and a high-yielding macrolactamization); a practical deprotection protocol allowed isolation of the target compound with excellent recovery and purity. The Royal Society of Chemistry.
