1095208-30-2

Upstream product

• 390424-25-6 3-(3-bromo-4-hydroxyphenyl)-2-oxopropionic acid 
• 146884-05-1 (E)-3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid 
• 4138-35-6 methyl 3-aminopropanoate 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 

Downstream Products

• 1356930-00-1 (E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide 

Relevant academic research and scientific papers

Studying Histone Deacetylase Inhibition and Apoptosis Induction of Psammaplin A Monomers with Modified Thiol Group

Psammaplin A (PsA) is a bromotyrosine disulfide dimer with histone deacetylase (HDAC) inhibition and acts through reduced monomer PsA-SH. We studied the connection of HDAC inhibition, cell growth inhibition, and apoptosis induction of PsA-SH by modifying the -SH group with deletion (6a) or replacement with hydroxamic acid (10b) or benzamide (12g). PsA-SH inhibits HDAC1/2/3 and 6a loses the HDAC inhibition ability. 10b inhibits HDAC1/2/3/6 while 12g shows selective inhibition of HDAC3. PsA-SH and 10b, but neither 6a nor 12g, induce apoptosis in human leukemia HL-60 cells associated with increased acetylation of Histone H3. PsA-SH and 10b inhibit growth of several solid tumor cell lines in vitro and Lewis lung cancer cell growth in vivo. PsA-SH is a simple scaffold for developing selective HDAC inhibitors and induces apoptosis through inhibiting HDAC1/2.