1095208-48-2

Upstream product

• 1058742-49-6 C₂₀H₁₁ClF₂O₃ 
• 95-53-4 o-toluidine 
• 22494-42-4 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid 
• 1058742-48-5 O-benzoyldiflunisal 

Relevant academic research and scientific papers

Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-inflammatory agents

To improve the medicinal activity, the structure of diflunisal has been modified. Twenty-one amide derivatives of diflunisal were synthesized starting from diflunisal in three steps with total yields from 72% to 89%. All compounds were identified by 1H NMR, MS, and elemental analysis. The anti-inflammatory and analgesic activities for 19 compounds were evaluated. It was found that 5m possesses an excellent anti-inflammatory activity and a good analgesic activity, maybe a potential anti-inflammatory agent.

Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-tumor agents

To discover the new medicinal activity, the structure of diflunisal has been modified. Forty amide derivatives of diflunisal were synthesized starting from diflunisal in three steps. Their inhibition growth rate of human lung cancer cell (A549) and human