109522-62-5Relevant articles and documents
Preparation method of gemcitabine intermediate
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Paragraph 0026-0028; 0030-0032; 0034-0036; 0038-0040; 0042, (2019/10/08)
The invention relates to a preparing method of a gemcitabine intermediate, and belongs to the technical field of medicine intermediate synthesis. In order to solve the problems that an existing methodis violent in reaction and not stable in yield, the preparing method of the gemcitabine intermediate is provided. The method includes the steps of adding iodine powder to an organic zinc intermediate-state reaction solution obtained through the reaction of ethyl bromodifluoroacetate and activated zinc powder in a first solvent, adding acetonylidene glyceraldehyde to a second solvent to obtain a corresponding acetonylidene glyceraldehyde solution, synchronous pumping the organic zinc intermediate-state reaction solution and the acetonylidene glyceraldehyde solution into a micro-channel reactorfor a condensation reaction to obtain outflow liquid, and conducting acidification to obtain the corresponding product (gemcitabine intermediate). The problem of the violent reaction can be effectively overcome, and the effects of mild reaction and high product yield are achieved.
AZETIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF
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Page/Page column 42-43, (2011/01/05)
Compounds of formula [I]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salts or solvates thereof.