92207-60-8

Upstream product

• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 
• 100-52-7 benzaldehyde 
• 667-27-6 Ethyl bromodifluoroacetate 
• 167308-39-6 ethyltrimethylsilyl-2,2-difluoroketene acetal 
• 109522-62-5 (2-ethoxy-1,1-difluoro-2-oxoethyl)zinc(II) bromide 
• 205865-67-4 α-(trimethylsilyl)difluoroacetic acid ethyl ester 
• 98-86-2 acetophenone 

Downstream Products

• 145049-27-0 2,2-Difluoro-3-phenyl-3-((E)-3-phenyl-allyloxy)-propionic acid ethyl ester 
• 915133-84-5 ethyl 2,2-difluoro-3-{[(methylthio)carbonothioyl]oxy}-3-phenyl propanoate 
• 1042662-75-8 ethyl (R)-2,2-difluoro-3-propionyloxy-3-phenylpropanoate 
• 263898-37-9 2,2-difluoro-3-hydroxy-N-methoxy-N-methyl-3-phenyl-propionamide 
• 915133-85-6 β,β-difluorobenzenepropanol 
• 134806-69-2 ethyl 2,2-difluoro-3-phenylpropionate 
• 330801-22-4 3-(tert-butyl-dimethyl-silanyloxy)-2,2-difluoro-3-phenyl-propionic acid ethyl ester 
• 114701-62-1 ethyl 2,2-difluoro-3-oxo-3-phenylpropanoate 
• 145049-29-2 3-((Z)-4-Benzyloxy-but-2-enyloxy)-2,2-difluoro-3-phenyl-propionic acid ethyl ester 
• 145049-28-1 2,2-Difluoro-3-(3-methyl-but-2-enyloxy)-3-phenyl-propionic acid ethyl ester 
• 1262850-24-7 C₁₁H₁₁ClF₂O₂ 

Relevant academic research and scientific papers

2,2-DIFLUORO-3-HYDROXYESTERS BY REFORMATSKII REACTION

Ethyl bromodifluoroacetate undergoes facile Reformatskii addition to aldehydes and ketones to form 2,2-difluoro-3-hydroxyesters.

Impact of the Difluoromethylene Group in the Organocatalyzed Acylative Kinetic Resolution of α,α-Difluorohydrins

Due to the omnipresence of chiral organofluorine compounds in pharmaceutical, agrochemical, and material chemistry, the development of enantioselective methods for their preparation is highly desirable. In the present study, the enantioselective organocatalyzed acylation of α,α-difluorohydrins using a commercially available chiral isothiourea is reported through a kinetic resolution (KR) process. It reveals that the difluoromethylene moiety (C(sp3)F2) can serve as a directing group through electrostatic fluorine–cation interactions, greatly improving the enantioselectivity of the KR. In this context, a broad range of fluorinated alcohols such as valuable 4,4-difluoro-1,3-diols could be synthesized with exquisite enantiocontrol (typically >99:1 er). Turning to 2,2-difluoro-1,3-diols, we also demonstrated that aromatic and fluorinated groups were mutually compatible to provide the expected enantioenriched adducts with >99:1 er.

Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation

Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched α,α-difluoro-β-arylbutanoic esters were prepar

A Ball-Milling-Enabled Reformatsky Reaction

An operationally simple one-jar one-step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre-activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39–82 % yield) and is effective irrespective of the initial morphology of the zinc source.

Decarboxylative aldol reaction of α,α-difluoro-β-ketocarboxylate salt: A facile method for generation of difluoroenolate

We developed a decarboxylative aldol reaction using α,α-difluoro-β-ketocarboxylate salt, carbonyl compounds, and ZnCl2/N,N,N′,N′-tetramethylethylenediamine. The generation of difluoroenolate proceeded smoothly under mild heating to provide α,α-

NOVEL COMPOUNDS

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, X1, X2, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12and R13 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

N-heterocyclic carbene-catalyzed fluorinated silyl-Reformatsky reaction of aldehydes with difluoro (trimethylsilyl) acetate

N-Heterocyclic carbenes (NHCs) have been employed as highly efficient organocatalysts for fluorinated silyl-Reformatsky reaction of carbonyl compounds. In the presence of 5–10 mol % NHC A, various aldehydes and 2,2,2–trifluoroacetophenone reacted with difluoro (trimethylsilyl) acetate to produce β–hydroxy gem–difluoro esters in 20–96% yields.

Chemically-amplified positive resist composition and resist patterning process using the same

The present invention provides a chemically-amplified positive resist composition including a sulfonium salt capable of providing a pattern having an extremely high resolution with low line edge roughness, and also provides a resist patterning process usi

Ligand-controlled regiodivergent palladium-catalyzed decarboxylative allylation reaction to access α,α-difluoroketones

α,α-Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. To access the α-allyl-α,α-difluoroketone substructure, complementary palladium-catalyzed decarboxylative allylation reactions were developed to provide linear and branched α-allyl-α,α-difluoroketones. For these orthogonal processes, the fluorination pattern of the substrate enabled the ligands to dictate the regioselectivity of the transformations.

SULFONIUM SALT, CHEMICALLY AMPLIFIED RESIST COMPOSITION, AND PATTERN FORMING PROCESS

A carboxylic acid sulfonium salt having formula (1) is provided wherein R0 is hydrogen or a monovalent hydrocarbon group, R01 and R02 are hydrogen or a monovalent hydrocarbon group, at least one of R0, R01