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CAS

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1095273-56-5

1-[1-({5-[3,5-bis(methyloxy)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1095273-56-5 Structure

  • Basic information

    1. Product Name: 1-[1-({5-[3,5-bis(methyloxy)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one
    2. Synonyms:
    3. CAS NO:1095273-56-5
    4. Molecular Formula:
    5. Molecular Weight: 464.481
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1095273-56-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-[1-({5-[3,5-bis(methyloxy)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-[1-({5-[3,5-bis(methyloxy)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one(1095273-56-5)
    11. EPA Substance Registry System: 1-[1-({5-[3,5-bis(methyloxy)phenyl]-1,3,4-oxadiazol-2-yl}acetyl)-4-piperidinyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one(1095273-56-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1095273-56-5(Hazardous Substances Data)

1095273-56-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1095273-56-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,5,2,7 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1095273-56:
(9*1)+(8*0)+(7*9)+(6*5)+(5*2)+(4*7)+(3*3)+(2*5)+(1*6)=165
165 % 10 = 5
So 1095273-56-5 is a valid CAS Registry Number.

1095273-56-5Downstream Products

1095273-56-5Relevant articles and documents

Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine

Nichols, Paula L.,Brand, Jonathan,Briggs, Michael,D'Angeli, Mathilde,Farge, Jennifer,Garland, Stephen L.,Goldsmith, Paul,Hutchings, Rio,Kilford, Ian,Li, Ho Y.,MacPherson, David,Nimmo, Fiona,Sanderson, Francis Dominic,Sehmi, Sanjeet,Shuker, Nicola,Skidmore, John,Stott, Michael,Sweeting, Jennifer,Tajuddin, Hasmi,Takle, Andrew K.,Trani, Giancarlo,Wall, Ian D.,Ward, Robert,Wilson, David M.,Witty, David

scheme or table, p. 1368 - 1372 (2010/07/02)

A pharmacophore model was built, based on known CGRP receptor antagonists, and this was used to aid the identification of novel leads. Analogues were designed, modelled and synthesised which incorporated alternative 'LHS' fragments linked via either an amide or urea to a privileged 'RHS' fragment commonly found in CGRP receptor antagonists. As a result a novel series of oxadiazole CGRP receptor antagonists has been identified and the subsequent optimisation to enhance both potency and bioavailability is presented.

5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS

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Page/Page column 25, (2009/03/07)

The present invention relates to novel compounds that are CGRP receptor antagonists, processes for their preparation, to compositions containing them and to their use in the treatment of migraine, headache, and cluster headache.

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