109532-79-8Relevant academic research and scientific papers
Synthesis of a 2,4,6-trisubstituted 5-cyano-pyrimidine library and evaluation of its immunosuppressive activity in a Mixed Lymphocyte Reaction assay
Stella, Alessandro,Van Belle, Kristien,De Jonghe, Steven,Louat, Thierry,Herman, Jean,Rozenski, Jef,Waer, Mark,Herdewijn, Piet
, p. 1209 - 1218 (2013/03/28)
A series of novel pyrimidine analogues were synthesized and evaluated for immunosuppressive activity in the Mixed Lymphocyte Reaction assay, which is well-known as the in vitro model for in vivo rejection after organ transplantation. Systematic variation of the substituents at positions 2, 4 and 6 of the pyrimidine scaffold led to the discovery of 2-benzylthio-5-cyano-6-(4- methoxyphenyl)-4-morpholinopyrimidine with an IC50 value of 1.6 μM in the MLR assay.
Chemotherapeutical Agents, V. - Syntheses and Activities of Novel Pyrimidines Derived from 5-Cyano-6-aryl-2-thiouracil
Ram, Vishnu J.,Berghe, Dirk A. Vanden,Vlietinck, Arnold J.
, p. 797 - 801 (2007/10/02)
The 5-cyano-6-aryl-2-thiouracils 1a-d were prepared for the syntheses of several other pyrimidine derivatives.In basic medium 1a reacted with picryl chloride yielding the unexpected benzothiazolo-pyrimidine 2.Heating a mixture of 1 and 1,2-dibromoethane i
