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1095381-35-3

tert-butyl 4-(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • tert-butyl 4-(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate

    Cas No: 1095381-35-3

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  • tert-butyl 4-(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate

    Cas No: 1095381-35-3

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  • Xi`an Eastling Biotech Co., Ltd.
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  • 1095381-35-3 Structure

  • Basic information

    1. Product Name: tert-butyl 4-(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate
    2. Synonyms: tert-butyl 4-(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate
    3. CAS NO:1095381-35-3
    4. Molecular Formula:
    5. Molecular Weight: 651.606
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1095381-35-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: tert-butyl 4-(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: tert-butyl 4-(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate(1095381-35-3)
    11. EPA Substance Registry System: tert-butyl 4-(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate(1095381-35-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1095381-35-3(Hazardous Substances Data)

1095381-35-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1095381-35-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,5,3,8 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1095381-35:
(9*1)+(8*0)+(7*9)+(6*5)+(5*3)+(4*8)+(3*1)+(2*3)+(1*5)=163
163 % 10 = 3
So 1095381-35-3 is a valid CAS Registry Number.

1095381-35-3Relevant articles and documents

Imidazo[4,5-b]pyridine derivatives as inhibitors of aurora kinases: Lead optimization studies toward the identification of an orally bioavailable preclinical development candidate

Bavetsias, Vassilios,Large, Jonathan M.,Sun, Chongbo,Bouloc, Nathalie,Kosmopoulou, Magda,Matteucci, Mizio,Wilsher, Nicola E.,Martins, Vanessa,Reynisson, Jóhannes,Atrash, Butrus,Faisal, Amir,Urban, Frederique,Valenti, Melanie,De Haven Brandon, Alexis,Box, Gary,Raynaud, Florence I.,Workman, Paul,Eccles, Suzanne A.,Bayliss, Richard,Blagg, Julian,Linardopoulos, Spiros,McDonald, Edward

supporting information; experimental part, p. 5213 - 5228 (2010/09/18)

Lead optimization studies using 7 as the starting point led to a new class of imidazo[4,5-b]pyridine-based inhibitors of Aurora kinases that possessed the 1-benzylpiperazinyl motif at the 7-position, and displayed favorable in vitro properties. Cocrystallization of Aurora-A with 40c (CCT137444) provided a clear understanding into the interactions of this novel class of inhibitors with the Aurora kinases. Subsequent physicochemical property refinement by the incorporation of solubilizing groups led to the identification of 3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b] pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole (51, CCT137690) which is a potent inhibitor of Aurora kinases (Aurora-A IC50 = 0.015 ± 0.003 μM, Aurora-B IC50 = 0.025 μM, Aurora-C IC50 = 0.019 μM). Compound 51 is highly orally bioavailable, and in in vivo efficacy studies it inhibited the growth of SW620 colon carcinoma xenografts following oral administration with no observed toxicities as defined by body weight loss.

IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES

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Page/Page column 35-36, (2009/03/07)

The 62 specific compounds disclosed in the description, which fall within the general structural formula (I) below, are inhibitors of aurora kinase enzymes: wherein X is -N-, -CH2-N-, -CH2-CH-, or -CH-; R1 is a radical of formula (IA) wherein Z is -CH2-,

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