109539-01-7Relevant academic research and scientific papers
Synthesis of Casein-Related Peptides and Phosphopeptides. VII. The efficient Synthesis of Ser(P)-Containing peptides by the Use of Boc-Ser(PO3R2)-OH Derivatives
Perich, John W.,Alewood, Paul F.,Johns, R. B.
, p. 233 - 252 (2007/10/02)
A new approach to the synthesis of Ser(PO3R2)-containing peptides by using five protected Boc-Ser(PO3R2)-OH (R = phenyl, ethyl, methyl, benzyl, t-butyl) derivatives is described.The five Boc-protected derivatives are prepared by a simple three-step synthe
An Efficient One-Pot Synthesis of N-Protected α-Amino-β-dialkoxyphosphinyloxy(diphenoxyphosphinyloxy)-carboxylic Acids (Phosphate-Group Esters of O-Phosphorylated N-Protected α-Amino-β-hydroxyamino Acids)
Perich, John W.,Alewood, Paul F.,Johns, R. B.
, p. 572 - 573 (2007/10/02)
Dialkyl or diphenyl phosphorochloridites readily phosphitylate N-Boc- and N-Z-serine in the presence of pyridine to give N-protected O,O'-disubstituted phosphoserines in high yields after iodine/water oxidation.This procedure was also extended to the preparation of N-protected O,O'-disubstituted phosphothreonines and N-protected O,O'-disubstituted phosphotyrosines.
