109540-19-4 Usage
Uses
Used in Pharmaceutical Research:
6-Bromo-2-(4-methoxyphenyl)quinoline-4-carboxylic acid is used as a building block in the synthesis of new drug molecules, leveraging its ability to interact with biological systems and its structural properties.
Used in Organic Synthesis:
In the field of organic synthesis, 6-Bromo-2-(4-methoxyphenyl)quinoline-4-carboxylic acid serves as a key intermediate for the creation of various complex organic compounds, contributing to the development of novel chemical entities with potential applications across different industries.
Used in Drug Discovery:
6-Bromo-2-(4-methoxyphenyl)quinoline-4-carboxylic acid is employed as a starting material in drug discovery processes, where its unique structure and functional groups are explored for the development of therapeutic agents with potential medicinal properties.
Used in Medicinal Chemistry:
In medicinal chemistry, 6-Bromo-2-(4-methoxyphenyl)quinoline-4-carboxylic acid is utilized for the design and optimization of pharmaceutical compounds, taking advantage of its chemical reactivity and structural features to create molecules with desired biological activities.
Used in Chemical Biology:
6-Bromo-2-(4-methoxyphenyl)quinoline-4-carboxylic acid is applied in chemical biology to study the interactions between small molecules and biological targets, providing insights into the molecular mechanisms of diseases and the development of targeted therapies.
Used in Biochemical Research:
In biochemical research, 6-Bromo-2-(4-methoxyphenyl)quinoline-4-carboxylic acid is used to investigate the binding and modulation of biological macromolecules, such as enzymes and receptors, contributing to the understanding of molecular recognition and signal transduction pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 109540-19-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,5,4 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 109540-19:
(8*1)+(7*0)+(6*9)+(5*5)+(4*4)+(3*0)+(2*1)+(1*9)=114
114 % 10 = 4
So 109540-19-4 is a valid CAS Registry Number.
109540-19-4Relevant academic research and scientific papers
Synthesis, characterization, and antileishmanial activity of certain quinoline-4-carboxylic acids
Abdelwahid, Mazin A. S.,Elsaman, Tilal,Mohamed, Malik S.,Latif, Sara A.,Mukhtar, Moawia M.,Mohamed, Magdi A.
, (2019/03/08)
Leishmaniasis is a fatal neglected parasitic disease caused by protozoa of the genus Leishmania and transmitted to humans by different species of phlebotomine sandflies. The disease incidence continues to increase due to lack of vaccines and prophylactic drugs. Drugs commonly used for the treatment are frequently toxic and highly expensive. The problem of these drugs is further complicated by the development of resistance. Thus, there is an urgent need to develop new antileishmanial drug candidates. The aim of this study was to synthesize certain quinoline-4-carboxylic acids, confirm their chemical structures, and evaluate their antileishmanial activity. Pfitzinger reaction was employed to synthesize fifteen quinoline-4-carboxylic acids (Q1-Q15) by reacting equimolar mixtures of isatin derivatives and appropriate α-methyl ketone. The products were purified, and their respective chemical structures were deduced using various spectral tools (IR, MS, 1H NMR, and 13C NMR). Then, they were investigated against L. donovani promastigote (clinical isolate) in different concentration levels (200 μg/mL to 1.56 μg/mL) against sodium stibogluconate and amphotericin B as positive controls. The IC50 for each compound was determined and manipulated statistically. Among these compounds, Q1 (2-methylquinoline-4-carboxylic acid) was found to be the most active in terms of IC50.
