109544-10-7

Basic information

• Product Name: [2-(4-chlorophenyl)-4-methyloxazol-5-yl]methanol
• Synonyms: [2-(4-chlorophenyl)-4-methyloxazol-5-yl]methanol
• CAS NO: 109544-10-7
• Molecular Weight: 223.659
• Mol File: 109544-10-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [2-(4-chlorophenyl)-4-methyloxazol-5-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-chlorophenyl)-4-methyloxazol-5-yl]methanol(109544-10-7)
• EPA Substance Registry System: [2-(4-chlorophenyl)-4-methyloxazol-5-yl]methanol(109544-10-7)

Safety Data

• Hazardous Substances Data: 109544-10-7(Hazardous Substances Data)

Upstream product

• 109544-20-9 ethyl 2-(4-chlorophenyl)-4-methyl-5-oxazolecarboxylate 
• 100-46-9 benzylamine 
• 109544-19-6 ethyl 2-(4-chlorobenzoyloxy)-3-oxo-butyrate 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 109543-76-2 romazarit 
• 109544-39-0 2-(4-chlorophenyl)-4-methyl-5-(chloromethyl)oxazole 

Relevant articles and documents

Synthesis of substituted oxazoles from N-benzyl propargyl amines and acid chlorides

The reaction between N-benzylpropargylamines and acid chlorides at elevated temperatures provides efficient, direct access to a variety of di- and tri-substituted oxazoles. The versatility of this reaction is explored and 21 examples are demonstrated. The usefulness of the methodology is showcased through the short and efficient formal syntheses of medicinally relevant drugs aleglitazar and romazarit. The reaction between N-benzylpropargylamines and acid chlorides at elevated temperatures gives oxazoles in up to 99 % yield. Twenty-one examples are demonstrated varying the substitution at all positions of the heterocycle. Copyright

Oxazole and isoxazole derivatives having anti-arthritic activity

Oxazole and isoxazole derivatives of the formula STR1 wherein A is C1-6 -alkylene, Het is a 2-R-oxazol-5-yl, 5-R-oxazol-2-yl, 4-R-oxazol-2-yl, 2-R-oxazol-4-yl, 3-R-isoxazol-5-yl or 5-R-isoxazol-3-yl group which is optionally substituted on the