1095708-32-9

Basic information

• Product Name: tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate
• Synonyms: tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate ;N-tert-butyl-N-[3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbaMate;2-(tert-ButoxycarbonylaMino)pyridine-4-boronic acid pinacol ester;Boc-2-AMinopyridine-4-boronic acid pinacol ester;tert-butyl N-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate;[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-carbamic acid tert-butyl ester 97%;(2-((TERT-BUTOXYCARBONYL)AMINO)PYRIDIN-4-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 1095708-32-9
• Molecular Formula: C₁₆H₂₅BN₂O₄
• Molecular Weight: 319.18376
• Mol File: 1095708-32-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 400.7±30.0 °C(Predicted)
• Appearance: /
• Density: 1.10
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 12.66±0.70(Predicted)
• CAS DataBase Reference: tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate(1095708-32-9)
• EPA Substance Registry System: tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate(1095708-32-9)

Safety Data

• Hazardous Substances Data: 1095708-32-9(Hazardous Substances Data)

Usage

General Description

Tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate is a chemical compound commonly used in organic synthesis and pharmaceutical research. It is a derivative of pyridine, a heterocyclic compound, and contains a tert-butyl group, which provides stability and steric hindrance. The presence of the dioxaborolane group in the molecule makes it a valuable building block for Suzuki-Miyaura cross-coupling reactions, a widely used method in organic chemistry. tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate has shown potential as a building block for the synthesis of pharmaceuticals and agrochemicals, making it an important target in chemical research and development.

Upstream product

• 84249-14-9 2-amino-4-bromopyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1195995-72-2 4-(4,4,5 ,5-tetramethyl-1,3 ,2-dioxaborolan-2-yl)pyridin-2-amine 
• 207799-10-8 (4-bromopyridin-2-yl)-carbamic acid tert-butyl ester 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1208069-60-6 {4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}amine 
• 1208069-63-9 {4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine 
• 1616930-52-9 C₂₈H₂₇F₂N₅O₃ 
• 1616929-95-3 5-[5-(2-amino-pyridin-4-yl)-2-methyl-phenyl]-N-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide 

Relevant articles and documents

SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a 6,5-heterocyclic structure (e.g., compounds having a imidazopyridine, imidazopyrimidine, imidazopyrazine, imidazopyridazine, imidazotriazine, benzoimidazole, benzotriazole, benzoisoxazole, purine, indazole, triazolotriazine, triazolopyridazine, triazolopyrimidine, triazolopyrazine, triazolotetrazine, triazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolopyridazine, pyrazolotriazine, pyrazolopyridine, isoxazolopyrazine, isoxazolopyrimidine, isoxazolopyrdiazine, isoxazolotriazine, or isoxalopyridine structure) which function as inhibitors of DYRK1A, DYRK1B, and Clk-1, and their use as therapeutics for the treatment of Alzheimer's disease, Down syndrome, diabetes, glioblastoma, autoimmune diseases, cancer (e.g., glioblastoma, prostate cancer), inflammatory disorders (e.g., airway inflammation), and other diseases.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

9H-PYRROLO-DIPYRIDINE DERIVATIVES

The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.