1195995-72-2

Basic information

• Product Name: 2-AMINOPYRIDINE-4-BORONIC ACID PINACOL ESTER
• Synonyms: 2-AMINOPYRIDINE-4-BORONIC ACID PINACOL ESTER;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine;4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylaMine;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine, 2-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-AMinopyridine-4-boronic acid pinacol este;4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine;2-AMINOPYRIDINE-4-BORONIC ACID PICOL ESTER;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine HCl salt 97%
• CAS NO: 1195995-72-2
• Molecular Formula: C11H17BN2O2
• Molecular Weight: 238
• Product Categories: Medical Intermediates
• Mol File: 1195995-72-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 364.8±27.0 °C(Predicted)
• Appearance: Colorless to pale yellow/Liquid May Contain Few Solid Specs
• Density: 1.09±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 6.28±0.14(Predicted)
• CAS DataBase Reference: 2-AMINOPYRIDINE-4-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINOPYRIDINE-4-BORONIC ACID PINACOL ESTER(1195995-72-2)
• EPA Substance Registry System: 2-AMINOPYRIDINE-4-BORONIC ACID PINACOL ESTER(1195995-72-2)

Safety Data

• Statements: 36
• Safety Statements: 26
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 1195995-72-2(Hazardous Substances Data)

Usage

Description

2-Aminopyridine-4-borononic Acid Pinacol Ester is an organic compound that serves as a useful boronic acid pinacol ester for the synthesis of various bioactive small molecules. It is a key intermediate in the preparation of pharmaceutical compounds and has been identified as BML00290.

Uses

Used in Pharmaceutical Synthesis:
2-Aminopyridine-4-borononic Acid Pinacol Ester is used as a key intermediate for the synthesis of bioactive small molecules, which can be utilized in the development of pharmaceuticals for various therapeutic applications.
Used in Rho Kinase Inhibitors:
In the pharmaceutical industry, 2-Aminopyridine-4-borononic Acid Pinacol Ester is used as a reagent in the preparation of indoleand 7-azaindolecarboxamides. These compounds act as Rho kinase inhibitors, which are important for the treatment of various diseases, including cardiovascular and neurological disorders.
Used in CDC7 Inhibitors:
2-Aminopyridine-4-borononic Acid Pinacol Ester also plays a role in the development of 3D pharmacophore model-assisted discovery of novel heteroaryl dihydrothieno-pyridinones. These compounds serve as CDC7 inhibitors, which have potential applications in the treatment of cancer due to their ability to disrupt cell division and DNA replication.

Upstream product

• 84249-14-9 2-amino-4-bromopyridine 
• 73183-34-3 bis(pinacol)diborane 
• 65370-42-5 4-chloro-2-nitropyridine 

Downstream Products

• 1095708-32-9 N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]carbamic acid 1,1-dimethylethyl ester 
• 908268-52-0 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)imidazo[1,2-a]pyridine 
• 1567836-91-2 2,4-difluoro-N-(4-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-2-yl)benzenesulfonamide 
• 1338581-58-0 4-[2-(4-fluorophenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine 

Relevant articles and documents

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2′-fluoro-3′-(substituted pyridinyl)-7- deschloroepibatidine analogues

2′-Fluoro-3-(substituted pyridine)epibatidine analogues 7a-e and 8a-e were synthesized, and their in vitro and in vivo nAChR properties were determined. 2′-Fluoro-3′-(4″-pyridinyl)deschloroepibatidine (7a) and 2′-fluoro-3′-(3″-pyridinyl)deschloroepibatidi

Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization

Small molecule stimulation of β-cell regeneration has emerged as a promising therapeutic strategy for diabetes. Although chemical inhibition of dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is sufficient to enhance β-cell replicat

Method for synthesizing aminopyridine borate

The invention discloses a method for synthesizing aminopyridine boronate. According to the method, after nitryl-halogenated pyridine is subjected to Suzuki coupling with metal palladium and bis(glycolato)diboron and simple filtration is performed, hydrogen is directly introduced for reduction, and the product is obtained. Through the operation of the method, the situation is avoided that in the product, the other half of bisdiboron removed during coupling and aminopyridine form a complex compound; the obtained product is high in purity and yield.