1095715-84-6

Basic information

• Product Name: 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-(2-methyphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
• Synonyms: 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-(2-methyphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
• CAS NO: 1095715-84-6
• Molecular Weight: 492.577
• Mol File: 1095715-84-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-(2-methyphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-(2-methyphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide(1095715-84-6)
• EPA Substance Registry System: 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-(2-methyphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide(1095715-84-6)

Safety Data

• Hazardous Substances Data: 1095715-84-6(Hazardous Substances Data)

Upstream product

• 1095717-42-2 2-(1,3-benzodioxol-5-yl)-6-{[(3-ethylphenyl)amino]carbonyl}-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl 4-methylbenzenesulfonate 
• 16419-60-6 2-Methylphenylboronic acid 
• 1095717-36-4 tert-butyl 2-amino-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 
• 1095717-37-5 tert-butyl 2-bromo-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 
• 1095717-47-7 2-chloro-4-(2-methylphenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-ium chloride 
• 1095717-35-3 2-chloro-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydro[4,3-d]pyrimidine-6(5H)-carboxamide 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 
• 80531-15-3 benzo[1,3]dioxole-5-carboxamidine hydrochloride 
• 23138-58-1 1-ethyl-3-isocyanatobenzene 
• 4421-09-4 piperonylonitrile 
• 1095717-41-1 2-(1,3-benzodioxol-5-yl)-N-(3-ethylphenyl)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide 
• 1095717-40-0 ethyl 1-{[(3-ethylphenyl)amino]carbonyl}-4-oxopiperidine-3-carboxylate 
• 67848-59-3 4-piperidone-3-carboxylic acid ethyl ester 
• 98977-34-5 1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate 

Relevant articles and documents

Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists

A weak antagonist of the pyrimidinergic receptor P2Y14 containing a dihydropyridopyrimidine core was identified through high-throughput screening. Subsequent optimization led to potent, non-UTP competitive antagonists and represent the first reported non-nucleotide antagonists of this receptor. Compound 18q was identified as a 10 nM P2Y14 antagonist with good oral bioavailability and provided sufficient exposure in mice to be used as a tool for future in vivo studies.