109574-96-1

Upstream product

• 626-61-9 4-Chloropyridine 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 109575-14-6 3-(2-Chlorobenzoyl)-4-(1H)-pyridinone 
• 112723-80-5 (2-Chloro-phenyl)-(4-chloro-pyridin-3-yl)-methanone 
• 109575-15-7 3-(2-Chlorobenzoyl)-1-methyl-4(1H)-pyridinone 
• 109575-10-2 (2-aminopyridin-3-yl)(2-chlorophenyl)methanone 

Relevant academic research and scientific papers

Synthesis of 4-Amino-3-pyridinyl and 4-Amino-5-pyrimidinyl Aryl Ketones and Related Compounds via an ortho-Lithiation Reaction

4-Chloropyridine and 4,6-dichloropyrimidine react regioselectively with lithium diisopropylamide to give 4-chloro-3-lithiopyridine and 4,6-dichloro-5-lithiopyrimidine, respectively.These intermediates react with benzaldehydes to give (4-chloro-3-pyridinyl

A convenient synthesis of 9H-thioxanthen-9-ones and their aza-analogues

An efficient method for the preparation of 9H-thioxanthen-9-ones and their three aza-analogues has been developed. The reaction of (2-fluorophenyl)(2- halophenyl)methanones, derived from 1-bromo-2-fluorobenzenes and 2- halobenzaldehydes by an easy two-step sequence, with Na2S· 9H2O in DMF at 60 °C gives 9H-thioxanthen-9-ones. This procedure can be applied to the synthesis of 5H-[1]benzothiopyrano[2,3-b](or [2,3-c])pyridin-5-ones or 10H-[1]-benzothiopyrano[3,2-c]pyridin-10-ones starting from 2-, 3- or 4-chloropyridines, respectively.

Pyridines and Pyrimidines Mediating Activity against an Efflux-Negative Strain of Candida albicans through Putative Inhibition of Lanosterol Demethylase

The first step in ergosterol biosynthesis in Saccharomyces cerevisiae consists of the condensation of two acetyl coenzyme A (acetyl-CoA) moieties by acetoacetyl-CoA thiolase, encoded by ERG10. The inhibition of the sterol pathway results in feedback activ