Synthesis of 4-Amino-3-pyridinyl and 4-Amino-5-pyrimidinyl Aryl Ketones and Related Compounds via an ortho-Lithiation Reaction

DOI: 10.1055/s-1986-31817

Source and publish data:

Synthesis p. 886 - 891 (1986)

Update date:2022-08-05

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Authors:

Radinov, Rumen

Haimova, Marietta

Simova, Ekaterina

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Article abstract of DOI:10.1055/s-1986-31817

4-Chloropyridine and 4,6-dichloropyrimidine react regioselectively with lithium diisopropylamide to give 4-chloro-3-lithiopyridine and 4,6-dichloro-5-lithiopyrimidine, respectively.These intermediates react with benzaldehydes to give (4-chloro-3-pyridinyl

Full text of DOI:10.1055/s-1986-31817

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Product name:(2-chlorophenyl)(4-chloropyridin-3-yl)methanol

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