109581-73-9

Basic information

• Product Name: Technetium
• Synonyms: Technetium Tc 99m Sestamibi
• CAS NO: 109581-73-9
• Molecular Formula: C36H66N6O699mTc.
• Molecular Weight: 0
• Mol File: 109581-73-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 135.6°Cat760mmHg
• Flash Point: 34.2°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: Technetium(CAS DataBase Reference)
• NIST Chemistry Reference: Technetium(109581-73-9)
• EPA Substance Registry System: Technetium(109581-73-9)

Safety Data

• Hazardous Substances Data: 109581-73-9(Hazardous Substances Data)

Usage

Brand name

Cardiolite (DuPont Merck).

InChI:InChI=1/6C6H11NO.Tc/c6*1-6(2,8-4)5-7-3;/h6*5H2,1-2,4H3;/i;;;;;;1+1

Upstream product

• 13718-28-0 sodium [99Tc]pertechnetate 
• 103694-84-4 tetrakis(2-methoxyisobutylisocyano) copper(I) tetrafluoroborate 

Related news

Intermediate oxidation states of Technetium (cas 109581-73-9) in concentrated sulfuric acid solutions07/30/2019

The electrochemical reduction of pertechnetate ions (TcO4−) and properties of such formed reduced Tc containing species (ions and molecules) have been studied in strongly acidic media (4 ÷ 12 M aqueous H2SO4) using electrochemical (cyclic voltammetry (CV); chronoamperometry (CA), chronopotentio...detailed

Process for separation of Technetium (cas 109581-73-9) from alkaline low level waste using di-tert-butyldibenzo-18-crown-6 + isodecyl alcohol/n-dodecane solvent07/28/2019

Di-tert-butyldibenzo-18-crown-6 ether (CE) dissolved in a mixture of isodecyl alcohol and n-dodecane has been investigated for separation of technetium from alkaline low level waste (LLW). Technetium present as TcO4− pairs with sodium ion-crown ether complex formed due to high sodium nitrate con...detailed

Intermediate oxidation states of Technetium (cas 109581-73-9) in alkaline solutions07/27/2019

The electrochemical reduction of pertechnetate ions (TcO4−) have been studied in strongly alkaline media (0.3 ÷ 10 M aqueous NaOH) using electrochemical (cyclic voltammetry (CV); chronoamperometry (CA), chronopotentiometry (CP)) and spectroelectrochemical (UV-Vis OTTLE and Au-SERS) techniques. ...detailed

From oxo to carbonyl and arene complexes; A journey through Technetium (cas 109581-73-9) chemistry07/26/2019

A personal note in celebration of Professor Herrmann's 70th birthday, the author describes how the successful preparation of H3C99TcO3 and the still unsolved task of preparing [Cp*99TcO3] powered ultimately a plethora of organometallic 99Tc chemistry. Driven by the need for technetium carbo...detailed

Bioremediation of strontium and Technetium (cas 109581-73-9) contaminated groundwater using glycerol phosphate07/24/2019

Groundwater at legacy nuclear facilities around the world is contaminated with radionuclides including strontium-90 and technetium-99, which are often present as co-contaminants. Here we investigated whether biostimulation of indigenous microbial communities by glycerol phosphate can co-treat 90...detailed

Technetium (cas 109581-73-9) immobilization by materials through sorption and redox-driven processes: A literature review07/23/2019

The objective of this review is to evaluate materials for use as a barrier or other deployed technology to treat technetium-99 (Tc) in the subsurface. To achieve this, Tc interactions with different materials are considered within the context of remediation strategies. Several naturally occurrin...detailed

Relevant articles and documents

99mTc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: In vitro study

[99mTc(N)(DBODC)(PNP5)]+ [DBODC is bis(N-ethoxyethyl)dithiocarbamato; PNP5 is bis(dimethoxypropylphosphinoethyl) ethoxyethylamine], abbreviated as 99mTc(N)-DBODC(5), is a lipophilic cationic mixed compound investigated as a myocardial imaging agent. The findings that this tracer accumulates in mitochondrial structures through a mechanism mediated by the negative mitochondrial membrane potential and that the rapid efflux of 99mTc(N)-DBODC(5) from nontarget tissues seems to be associated with the multidrug resistance (MDR) P-glycoprotein (P-gp) transport function open up the possibility to extend its clinical applications to tumor imaging and noninvasive MDR studies. The rate of uptake at 4 and 37 C of 99mTc(N)-DBODC(5) was evaluated in vitro in selected human cancer cell lines and in the corresponding sublines before and after P-gp and/or MDR-associated protein (MRP) modulator/inhibitor treatment using 99mTc-sestamibi as a reference. The results indicated that (1) the uptake of both 99mTc(N)-DBODC(5) and 99mTc-sestamibi is correlated to metabolic activity of the cells and (2) the cellular accumulation is connected to the level of P-gp/MRP expression; in fact, an enhancement of uptake in resistant cells was observed after treatment with opportune MDR inhibitor/modulator, indicating that the selective blockade of P-gp/MRP prevented efflux of the tracers. This study provides a preliminary indication of the applicability of 99mTc(N)-DBODC(5) in tumor imaging and in detecting P-gp/MRP-mediated drug resistance in human cancer. In addition, the possibility to control the hydrophobicity and pharmacological activity of this heterocomplex through the variation of the substituents on the ligands backbone without affecting the P2S2 coordinating sphere makes 99mTc(N)-DBODC(5) a suitable scaffold for the preparation of a molecular probe for single photon emission computed tomography of MDR.