1096-49-7

Basic information

• Product Name: (2,7-diamino-1-hydroxy-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-9-yl)methyl carbamate
• Synonyms: 1H-Pyrrolo(1,2-a)indole-5,8-dione, 2,7-diamino-9-(((aminocarbonyl)oxy)methyl)-2,3-dihydro-1-hydroxy-6-methyl-, trans-
• CAS NO: 1096-49-7
• Molecular Formula: C₁₄H₁₆N₄O₅
• Molecular Weight: 320.3006
• Mol File: 1096-49-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 560.8°C at 760 mmHg
• Flash Point: 293°C
• Density: 1.9g/cm³
• Vapor Pressure: 2.06E-13mmHg at 25°C
• Refractive Index: 1.826
• CAS DataBase Reference: (2,7-diamino-1-hydroxy-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-9-yl)methyl carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (2,7-diamino-1-hydroxy-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-9-yl)methyl carbamate(1096-49-7)
• EPA Substance Registry System: (2,7-diamino-1-hydroxy-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-9-yl)methyl carbamate(1096-49-7)

Safety Data

• Hazardous Substances Data: 1096-49-7(Hazardous Substances Data)

Upstream product

• 114612-47-4 2,7-diamino-1-hydroxymitosene 1-uridilate 
• 50-07-7 mitomycin C 
• 170899-74-8 mitomycin C 

Relevant articles and documents

Nucleotide derivatives of 2,7-diaminomitosene

Treatment of mitomycin C with pyrimidine nucleotides in acidic media produced derivatives of 2,7-diaminomitosene in which C-1 was covalently bound to the phosphate group of the nucleotides. On reduction, these derivaties liberated the nucleotides and a mitomycin intermediate that alkylated DNA. Their reduction in the presence of 2'-deoxyguanosine produced some bifunctional alkylation as did mitomycin C. They were readily taken up by L1210 leukemia cells, in which they showed potent cytotoxicity. These properties suggest that they are acting as prodrugs capable of conversion into two active species. The uridylate derivative showed activity comparable to that of mitomycin C against P-388 leukemia in mice.