109620-01-1

Basic information

• Product Name: dihydrolatifolin
• Synonyms: dihydrolatifolin
• CAS NO: 109620-01-1
• Molecular Weight: 288.343
• Mol File: 109620-01-1.mol

Chemical Properties

• CAS DataBase Reference: dihydrolatifolin(CAS DataBase Reference)
• NIST Chemistry Reference: dihydrolatifolin(109620-01-1)
• EPA Substance Registry System: dihydrolatifolin(109620-01-1)

Safety Data

• Hazardous Substances Data: 109620-01-1(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 5533-04-0 2-(methoxymethoxy)benzaldehyde 

Relevant articles and documents

First total synthesis of (±)-latifolin and its antioxidant mechanism

The first total synthesis of (±)-latifolin has been accomplished in six steps and 47.8% overall yield. To understand the relative importance of phenolic O-H and benzhydryl C-H hydrogen on the antioxidant activity of latifolin, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and density functional theory (DFT) studies were carried out. On scavenging DPPH radical in ethanol, the activity of latifolin (1) bearing phenolic hydrogen is remarkably higher than analogue 10 bearing no phenolic hydrogen. Therefore, Phenolic hydrogen is responsible for latifolin's antioxidant activity rather than benzhydryl C-H hydrogen. Furthermore, the 5-OH BDE is lower than 2′-OH and 7-CH BDEs by a DFT calculation, respectively. Based on theoretical results it is definitely concluded that the phenolic 5-OH plays a major role in the antioxidant activity of latifolin. The first total synthesis of (±)-latifolin has been accomplished in six steps and 47.8% overall yield. Based on DPPH-scavenging assay and density functional theory (DFT) studies, the H-atom abstraction of latifolin should take place in the phenolic 5-OH rather than benzhydryl 7-CH.