109625-60-7

Upstream product

• 105427-90-5 methyl 2,4-bis[2-(trimethylsilyl)ethoxymethoxy]-3-bromo-5-chloro-6-methylbenzoate 
• 105427-88-1 methyl 3-bromo-5-chloro-2,4-dihydroxy-6-methylbenzoate 
• 58106-55-1 2,4-dihydroxy-3-bromo-6-methyl-benzoic acid methyl ester 
• 102227-58-7 (E,E)-2,6,10-trimethyl-12-(tetrahydropyran-2-yloxy)dodeca-6,10-dien-3-yne-2,5-diol 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 107669-74-9 (E,E)-2,6,10-trimethyl-5-pivaloyloxy-12-(tetrahydropyran-2-yloxy)dodeca-6,10-dien-3-yn-2-ol 
• 107669-75-0 5-<(E,E)-1,5-dimethyl-7-(tetrahydropyran-2-yloxy)hepta-1,5-dienyl>-2,2-dimethyl-3-pivaloyloxy-2,5-dihydrofuran 
• 109625-61-8 5-<(E,E)-7-hydroxy-1,5-dimethylhepta-1,5-dienyl>-2,2-dimethyl-3-pivaloyloxy-2,5-dihydrofuran 
• 105878-81-7 5-<(E,E)-7-bromo-1,5-dimethylhepta-1,5-dienyl>-2,2-dimethyl-3-pivaloyloxy-2,5-dihydrofuran 
• 113899-02-8 methyl 3-chloro-5-<(E,E)-7-(2,5-dihydro-5,5-dimethyl-4-pivaloyloxyfuran-2-yl)-3-methylocta-2,6-dienyl>-2-methyl-4,6-bis<2-(trimethylsilyl)ethoxymethoxy>benzoate 

Downstream Products

• 86832-77-1 dl-5-chloro-2,4-dihydroxy-6-methyl-3-[(2E,6E)-3-methyl-7-(3,3-dimethyl-4-oxo-2-oxacyclopentyl)-2,6-octadienyl]benzaldehyde 
• 169564-42-5 3-chloro-5-<(E,E)-7-(4,5-dihydro-5,5-dimethyl-4-oxofuran-2-yl)-3-methylocta-2,6-dienyl>-2-methyl-4,6-bis<2-(trimethylsilyl)ethoxymethoxy>benzaldehyde 

Relevant academic research and scientific papers

Total synthesis of dl-ascofuranone and related compounds

Convergent synthesis of an antitumor protective agent, ascofuranone, was accomplished by (1) preparation of the terpenoid side chain having a furanone moiety, (2) coupling the side chain with a protected phenol derivative, and (3) deprotection to regenerate the hydroxyl groups. This strategy was successfully applied to the synthesis of oxidized and cyclized analogs of ascofuranone. Some of the ascofuranone derivatives were found to inhibit the growth of P388 leukemia cells.

A MILD PROCEDURE FOR HYDROLYSIS OF ALKOXYMETHYL ARYL ETHERS TO GIVE HYDROXYARENES. A RATIONAL SYNTHESIS OF ASCOFURANONE

A mild procedure is reported for cleavage of alkoxymethyl aryl ethers with P2I4 to afford hydroxyarenes, and this deprotection method was successfully applied to the synthesis of an antibiotic ascofuranone through a rational approach.