109637-83-4

Basic information

• Product Name: artelinic acid
• Synonyms: Benzoicacid, 4-[[(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl)oxy]methyl]-,[3R-(3a,5ab,6b,8ab,9a,10a,12b,12aR*)]-;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, benzoic acid deriv.; Artelinicacid; b-Artelinic acid
• CAS NO: 109637-83-4
• Molecular Formula: C23H30O7
• Molecular Weight: 418.483
• Mol File: 109637-83-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 564.1°Cat760mmHg
• Flash Point: 192.2°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 1.45E-13mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: artelinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: artelinic acid(109637-83-4)
• EPA Substance Registry System: artelinic acid(109637-83-4)

Safety Data

• Hazardous Substances Data: 109637-83-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C23H30O7/c1-12-8-16-10-13(2)21(27-11-14-4-6-15(7-5-14)20(25)26)28-23-18(16)17(9-12)19(24)22(3,29-23)30-23/h4-7,12-13,16-19,21,24H,8-11H2,1-3H3,(H,25,26)

Upstream product

• 3006-96-0 3-hydroxymethyl-benzoic acid 
• 71939-50-9 dihydroartemisinin 
• 63968-64-9 artemisinin 
• 85031-59-0 dihydroartemisinic acid 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 63968-64-9 artemisinin 
• 71939-50-9 dihydroartemisinin 
• 216963-48-3 methyl p-<(10-dihydroartemisininoxy)methyl>benzoate 
• 81496-81-3 dihydroartesiminin 
• 63968-64-9 C₁₂H₁₃O₂(CH₃)3(O)(OO) 

Related news

Nuclear magnetic resonance and molecular modeling analysis of the interaction of the antimalarial drugs artelinic acid (cas 109637-83-4) and artesunic acid with β‐cyclodextrin07/22/2019

The artemisinin derivatives artelinic acid and artesunic acid are members of a class of compounds that have shown promise for the treatment of multidrug resistant strains of Plasmodium falciparum. Unfortunately, these compounds exhibit poor solubility and stability in aqueous solution. The resea...detailed

Relevant articles and documents

Synthesis of water soluble c-10-phenoxy artemisinin-chitosan conjugate

A sort of C-10-phenoxy artemisinin-chitosan conjugate, in which C-10-phenoxy artemisinin was covalently bound to chitosan, was prepared and its aqueous solubility was evaluated. The results indicated that the conjugate (1.013 mg/mL) had much higher aqueous solubility than artemisinin (0.0084 mg/mL) and C-10-phenoxy artemisinin (0.0245 mg/mL). The conjugate will be potentially useful for their application as the prodrug of artemisinin.

Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives

The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition

A series of artemisinin-vinyl sulfone hybrid molecules with the potential to act in the parasite food vacuole via endoperoxide activation and falcipain inhibition was synthesized and screened for antiplasmodial activity and falcipain-2 inhibition. All conjugates were active against the Plasmodium falciparum W2 strain in the low nanomolar range and those containing the Leu-hPhe core inhibited falcipain-2 in low micromolar range.