1096446-01-3

Basic information

• Product Name: 4-prolylmorpholine(SALTDATA: HCl)
• Synonyms: 4-prolylmorpholine(SALTDATA: HCl);morpholino-(2-pyrrolidinyl)methanone;morpholino-pyrrolidin-2-yl-methanone
• CAS NO: 1096446-01-3
• Molecular Formula: C9H17ClN2O2
• Molecular Weight: 220.69648
• Mol File: 1096446-01-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-prolylmorpholine(SALTDATA: HCl)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-prolylmorpholine(SALTDATA: HCl)(1096446-01-3)
• EPA Substance Registry System: 4-prolylmorpholine(SALTDATA: HCl)(1096446-01-3)

Safety Data

• Hazardous Substances Data: 1096446-01-3(Hazardous Substances Data)

Usage

General Description

4-prolylmorpholine (SALTDATA: HCl) is a chemical compound that consists of a prolyl group attached to a morpholine ring, and it is commonly found as the hydrochloride salt form. This chemical is often used as an intermediate in the synthesis of pharmaceutical compounds, such as antihistamines and antipsychotics. It has also been studied for its potential as a corrosion inhibitor and as a chelating agent in metal extraction processes. 4-prolylmorpholine (SALTDATA: HCl) has the potential to be a versatile and useful chemical in various industrial and research applications due to its unique structure and properties.

Upstream product

• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 537040-24-7 (S)-tert-butyl 2-(morpholine-4-carbonyl)pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 105414-01-5 Cbz-L-Pro-OCO₂-i-Bu 
• 66165-42-2 (S)-4-morpholine 

Downstream Products

• 91790-91-9 (S)-4-[(2-pyrrolidinyl)methyl]morpholine 

Relevant articles and documents

Towards novel 5-HT7 versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: Design, synthesis, and antidepressant properties. Part II

A 26-membered library of novel long-chain arylpiperazines, which contained primary and tertiary amides of cyclic amino acids (proline and 1,2,3,4-tetrahydroisoquinoline-3-carboxamide) in the terminal fragment was synthesized and biologically evaluated for binding affinity for 5-HT7 and 5-HT1A receptors. Docking studies confirmed advantages of Tic-amide over Pro-amide fragment for interaction with 5-HT7 receptors. Selected compounds 32 and 28, which behaved as 5-HT7Rs antagonist and 5-HT1A partial agonist, respectively, produced antidepressant-like effects in the forced swim test in mice after acute treatment in doses of 10 mg/kg (32) and 1.25 mg/kg (28). Compound 32 reduced immobility in a manner similar to the selective 5-HT7 antagonist SB-269970.

One-pot enantioselective synthesis of 3-nitro-2H-chromenes catalyzed by a simple 4-hydroxyprolinamide with 4-nitrophenol as cocatalyst

The asymmetric domino oxa-Michael-Henry reaction of salicylaldehyde derivatives with trans-β-nitro olefins catalyzed by a readily available trans-4-hydroxy-L-prolinamide with 4-nitrophenol as an effective cocatalyst is presented. The corresponding 3-nitro

Asymmetric trasformation of symmetrical epoxides to allylic alcohols by lithium (S)-2-(N,N-disubstituted aminomethyl)pyrrolidide

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