109662-83-1

Basic information

• Product Name: (E)-3-cyanomethylene-2-hydroxy-1-p-toluenesulfonylindoline
• Synonyms: (E)-3-cyanomethylene-2-hydroxy-1-p-toluenesulfonylindoline
• CAS NO: 109662-83-1
• Molecular Weight: 326.376
• Mol File: 109662-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-cyanomethylene-2-hydroxy-1-p-toluenesulfonylindoline(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-cyanomethylene-2-hydroxy-1-p-toluenesulfonylindoline(109662-83-1)
• EPA Substance Registry System: (E)-3-cyanomethylene-2-hydroxy-1-p-toluenesulfonylindoline(109662-83-1)

Safety Data

• Hazardous Substances Data: 109662-83-1(Hazardous Substances Data)

Upstream product

• 50562-79-3 1-(4-tolylsulfonyl)indole-3-carboxaldehyde 
• 2942-58-7 diethyl cyanophosphonate 
• 2408-36-8 lithium cyanide 

Downstream Products

• 109662-86-4 2-cyanomethylene-1-p-toluenesulfonyloxindole 

Relevant articles and documents

Synthesis and Cycloaddition Reaction of 2-Cyano-3-indoleacetonitriles

The reactions of 3-acylindoles with diethyl phosphorocyanidate (DEPC) in the presence of lithium cyanide (LiCN) are described.Treatment of 1 with DEPC and LiCN gave a mixture of (E)- and (Z)-3-cyanomethylene-1-diethylphosphono-2-hydroxyindolines (2 and 3).On the other hand, reaction of 12, 13, and 20a-d with DEPC and LiCN afforded 2-cyano-3-indoleacetonitrile derivatives (16, 19 and 21a-d).Strong base-induced cycloaddition reactions of 2-cyano-1-methyl-3-indoleacetonitrile (21a) with carbon-carbon triple bonds were carried out and gave the corresponding condensation products, 1-amino-4-cyanocarbazoles (22a-e), 6-amino-11-cyanobenzocarbazole (23), pyridocarbazole (25), and pyridocarbazole (26), in moderate yields.Keywords-diethyl phosphorocyanidate; cyanophosphorylation; 3-cyanomethyleneindoline; 2-cyano-3-indoleacetonitrile; orthoquinodimethane; acetylenic dienophile; 1-amino-4-cyano-carbazole; benzocarbazole; pyridocarbazole; pyridocarbazole