109684-66-4

Upstream product

• 1449-46-3 benzyltriphenylphosphonium bromide 
• 114762-39-9 ((2S,3S)-3-(3-(tert.-butyldiphenylsilyloxy)propyl)-2-methyloxiran-2-yl)methanol 
• 82188-73-6 (2S,3S)-2,3-epoxygeraniol 

Relevant academic research and scientific papers

Stereospecific Synthesis of α-Hydroxy-Cyclopropylboronates from Allylic Epoxides

Herein, we report a catalytic and stereospecific method for the preparation of enantioenriched α-hydroxy cyclopropylboronates with control in four contiguous stereocenters. The reaction involves the borylation of readily available allylic epoxides using an inexpensive Cu(I) salt and a commercially available phosphine ligand. High diastereocontrol is achieved and different diastereomers can be selectively prepared. Functionalization of the carbon–boron bond provides access to different enantiomerically enriched trisubstituted cyclopropanes from a common intermediate.

Styrene derivatives, their use as antiallergic agents and intemediate epoxides for their synthesis

Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: STR1 wherein R1 =H or CH3 ; R2 =phenyl, substituted phenyl, benzyl or a cysteinyl moiety; R4 and R5 =alkyl; n=O or 1; and R3 is as described.