1097-51-4

Basic information

• Product Name: 16a,17a-Epoxyprogesterone
• Synonyms: 16,17-Epoxypregn-4-ene-3,20-dione;16-alpha,17-epoxy-pregn-4-ene-20-dione;16-alpha,17-epoxypregn-4-ene-3,20-dione;16,17-EPOXYPROGESTERONE;16,17-ALPHA-EPOXYPROGESTERONE;16a,17a-epoxy-4-pregnen-3,20-dione;16A,17A-EPOXY PROGESTERONE;16ALPHA,17ALPHA-EPOXYPROGESTERONE
• CAS NO: 1097-51-4
• Molecular Formula: C₂₁H₂₈O₃
• Molecular Weight: 328.45
• EINECS: 214-147-5
• Product Categories: Biochemistry;Steroids;Steroids (Others)
• Mol File: 1097-51-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 200C
• Boiling Point: 466.9 °C at 760 mmHg
• Flash Point: 204.4 °C
• Appearance: white crystalline powder
• Density: 1.18 g/cm³
• Vapor Pressure: 6.82E-09mmHg at 25°C
• Refractive Index: 168 ° (C=1, CHCl3)
• Storage Temp.: −20°C
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 16a,17a-Epoxyprogesterone(CAS DataBase Reference)
• NIST Chemistry Reference: 16a,17a-Epoxyprogesterone(1097-51-4)
• EPA Substance Registry System: 16a,17a-Epoxyprogesterone(1097-51-4)

Safety Data

• WGK Germany: 3
• RTECS: TU5022000
• Hazardous Substances Data: 1097-51-4(Hazardous Substances Data)

Usage

Uses

16α,17α-Epoxyprogesterone is hydrolyzed by Rhizopus nigricans for the synthesis of many steroidal drugs.

InChI:InChI=1/C21H28O3/c1-12(22)21-18(24-21)11-17-15-5-4-13-10-14(23)6-8-19(13,2)16(15)7-9-20(17,21)3/h10,15-18H,4-9,11H2,1-3H3

Upstream product

• 2872-76-6 20α-hydroxy-16α,17α-epoxypregn-4-en-3-one 
• 38521-84-5 3-acetyloxypregna-5,16-diene-20-one 
• 6996-36-7 3β-(toluene-4-sulfonyloxy)-pregna-5,16-dien-20-one 
• 911442-53-0 3β-hydroxypregn-5-ene-16,20-dione 
• 78792-99-1 6β-methoxy-3α,5α-cyclo-pregn-16-en-20-one 
• 979-02-2 16-dehydropregnenolone acetate 
• 1044-90-2 (3β,5α,16α)-16,17-epoxy-3-hydroxypregnan-20-one 
• 974-23-2 3β-hydroxy-16α,17α-epoxypregn-5-en-20-one 
• 1096-38-4 16-dehydroprogesterone 

Downstream Products

• 28018-91-9 16β-Brom-17α-hydroxy-pregnen-(4)-dion-(3,20) 
• 3684-83-1 11α-hydroxy-16α,17α-epoxyprogesterone 
• 1225520-49-9 C₄₂H₅₆O₄S₃ 
• 1225520-55-7 C₄₉H₆₁O₅PS₃ 
• 1225520-41-1 3-thioxo-16α,17α-epoxyprogesterone 
• 3684-84-2 16α,17-epoxypregn-4-ene-3,11,20-trione 
• 570-58-1 5β-17α-hydroxy-preganene-3,20-dione 
• 68-96-2 17-hydroxyprogesterone 
• 1096-38-4 16-dehydroprogesterone 
• 438-07-3 16α-hydroxyprogesterone 
• 152-58-9 Cortexolone 
• 100167-82-6 16α,17α-epoxypregn-4-en-21-ol-3,20-dione 
• 119005-10-6 20,20-dimethoxy-16α,17α-epoxypregn-4-en-21-ol-3-one 

Relevant articles and documents

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Preparation method of betamethasone intermediate

The invention relates to a preparation method of a steroid drug intermediate, and concretely relates to a preparation method of a betamethasone intermediate which is 16beta-methyl-17alpha-hydroxypregna-4,9-diene-3,20-dione. The method comprises the following steps: carrying out a cyanidation reaction on 9alpha-hydroxy-4-ene-pregna-3,17-dione, carrying out a ketal protection reaction, carrying out a double elimination reaction, carrying out an epoxy reaction, and carrying out a Grignard addition hydrolysis reaction to prepare the target product. The method is a brand preparation technology for producing the betamethasone intermediate, and has the characteristics of cheap and easily available initial raw material, simple operations of all above reactions, high yield, suitableness for industrial massive production, and realization of the yield and the quality reaching satisfactory levels.

STEROID TRANSFORMATIONS. 187. MICROBIAL CONVERSION OF 3β-HYDROXY-5α-H-PREGNANES TO THEIR Δ4-3-KETO-9α-HYDROXY DERIVATIVES

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