1097119-36-2

Usage

Uses

Used in Pharmaceutical Industry:
(4-bromophenyl)(1H-indol-3-yl)methanone serves as a crucial intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications, making it an essential component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, (4-bromophenyl)(1H-indol-3-yl)methanone is utilized as an intermediate for the production of agrochemicals. Its role in creating effective and targeted pesticides or other agricultural products highlights its importance in this industry.
Used in Organic Synthesis:
(4-bromophenyl)(1H-indol-3-yl)methanone is used as a building block in organic synthesis for creating complex organic molecules. Its structural properties make it a valuable component in the development of new and innovative chemical compounds.
Used in Drug Discovery:
(4-bromophenyl)(1H-indol-3-yl)methanone's potential biological activity positions (4-bromophenyl)(1H-indol-3-yl)methanone as a key player in drug discovery. Researchers explore its properties to identify new therapeutic agents and contribute to advancements in medicinal chemistry.

Upstream product

• 120-72-9 indole 
• 7099-87-8 4-bromophenylglyoxylic acid 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 586-75-4 4-chlorobenzoyl chloride 
• 1373223-99-4 C₂₈H₂₄Br₂N₄S 
• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

Synthesis of 3-acylindoles: via copper-mediated oxidative decarbethoxylation of ethyl arylacetates

An efficient regioselective C-3 acylation of free indoles (N-H) has been accomplished via oxidative decarbethoxylation of easily available ethyl arylacetates using Cu(OAc)2 and KOtBu in DMSO.

Decarboxylative/decarbonylative C3-acylation of indoles: Via photocatalysis: A simple and efficient route to 3-acylindoles

A simple and efficient strategy for the preparation of 3-acylindoles via visible-light promoted C3-acylation of free (NH)- and N-substituted indoles with α-oxocarboxylic acids was developed. The reaction tolerates a wide range of functional groups, and the corresponding 3-acylindoles were obtained in high yields under mild conditions.

Copper-catalyzed decarboxylative C3-acylation of free (N-H) indoles with α-oxocarboxylic acids

An efficient Cu-catalyzed decarboxylative C3-acylation of free (N-H) indoles using α-oxocarboxylic acids as acylating agents has been developed. This method was compatible with a variety of functional groups and provided an attractive alternative access to 3-acylindoles in moderate to high yields.

Temperature-dependent product selectivity in the Vilsmeier-Haack reaction on bis(phenylhydrazones) of bis(aroylmethyl) sulfides (=1,1'-[thiobis(methylene) ]bis[arylmethanone] bis(2-phenylhydrazones)): Synthesis of 3-aroylindoles (=aryl(1H-indol-3-yl)methanones)

The bis(phenylhydrazone) of substituted diphenacyl sulfides (=1,1'-[thiobis(methylene)]bis[arylmethanone] bis(2-phenylhydrazones)) 1 underwent a tandem sequence of reactions upon treatment with Vilsmeier reagent, ultimately yielding 3-aroylindoles (=aryl(1H-indol-3-yl)methanones) 3 (Scheme 1 and Table 1). The reaction seems to be product selective depending upon the reaction temperature. Copyright

A novel microwave-irradiated solvent-free 3-acylation of indoles on alumina

A simple and efficient 3-acylation of indoles under microwave-heated and solvent-free conditions is developed. This general procedure uses neutral Al2O3 as a new, green and reusable catalyst giving good to high yields within short reaction times. Utilizing such an environmentally- benign methodology, a variety of indoles bearing electron-releasing or electron-withdrawing groups were conveniently acylated.