7099-87-8

Usage

Uses

Used in Pharmaceutical Research:
2-(4-Bromophenyl)-2-oxoacetic acid is used as a building block for the synthesis of various pharmaceuticals. Its presence allows for the introduction of specific functional groups, which can enhance the activity and efficacy of the resulting drugs.
Used in Agrochemical Production:
In the agrochemical industry, 2-(4-Bromophenyl)-2-oxoacetic acid serves as an intermediate in the production of various agrochemicals. Its unique structure contributes to the development of effective and targeted pest control solutions.
Used in Organic Synthesis:
2-(4-Bromophenyl)-2-oxoacetic acid is utilized as an intermediate in the synthesis of other organic compounds. Its bromine atom facilitates the introduction of desired functional groups, making it a key component in the creation of advanced materials and fine chemicals.
Used in Manufacturing Advanced Materials:
2-(4-Bromophenyl)-2-oxoacetic acid's ability to introduce specific functional groups also makes it useful in the manufacturing of advanced materials. 2-(4-Bromophenyl)-2-oxoacetic acid plays a crucial role in developing products with improved properties and performance in various applications.

Upstream product

• 69374-79-4 2-(4-bromophenyl)-2-oxoacetamide 
• 99-73-0 para-bromophenacyl bromide 
• 108-86-1 bromobenzene 
• 4755-77-5 Ethyl oxalyl chloride 
• 6940-50-7 4-bromo-DL-mandelic acid 
• 6048-21-1 4-bromobenzoyl cyanide 
• 59036-95-2 1-[2-(4-bromo-phenyl)-2-oxo-ethyl]-pyridinium 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 106-37-6 1.4-dibromobenzene 
• 20201-26-7 ethyl 4-bromophenylglyoxylate 
• 58881-56-4 2,2'-thiobis[1-(4-bromophenyl)ethanone] 
• 589-87-7 1,4-bromoiodobenzene 
• 124-38-9 carbon dioxide 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 4254-18-6 1,2-bis(4-bromophenyl)-2-hydroxyethan-1-one 
• 20201-26-7 ethyl 4-bromophenylglyoxylate 
• 62551-73-9 2-oxo-2-(4-bromophenyl)acetyl chloride 
• 77483-96-6 5-(4-Bromo-phenyl)-6-hydroxy-pyrazine-2,3-dicarbonitrile 
• 1122-91-4 4-bromo-benzaldehyde 
• 72111-69-4 5-(4-bromo-phenyl)-6-chloro-pyrazine-2,3-dicarbonitrile 
• 72113-78-1 5-(4-bromo-phenyl)-6-propylamino-pyrazine-2,3-dicarbonitrile 
• 101315-56-4 3-(4-bromophenyl)quinolin-2(1H)-one 
• 101315-52-0 2-(4-Bromphenylglyoxyloylamino)benzyltriphenylphosphoniumbromid 
• 1173294-92-2 (4-bromophenyl)(2-(pyridin-2-yl)phenyl)methanone 
• 92433-07-3 N-(2-(4'-bromobenzoyl)phenyl)acetamide 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 1258875-43-2 3-(4-chlorophenyl)-6-(4-bromophenyl)-7H-thiazolo[3,2-b][1,2,4]triazin-7-one 
• 1258875-45-4 6-(4-bromophenyl)-3-(4-methylphenyl)-7H-thiazolo[3,2-b][1,2,4]triazin-7-one 

Relevant academic research and scientific papers

Silyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives

3-Aryloxindole derivatives were synthesized through a Friedel-Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc) 2. Wide varieties of diethyl phosphates derived from N -arylmandelamides were converted almost quantitatively into oxindoles. When N, N -dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups.

Synthesis of α-Keto Acids via Oxidation of Alkenes Catalyzed by a Bifunctional Iron Nanocomposite

An efficient methodology for synthesis of α-keto acids via oxidation of alkenes using TBHP as oxidant catalyzed by a bifunctional iron nanocomposite has been established. A variety of alkenes with different functional groups were smoothly oxidized into their corresponding α-keto acids in up to 80% yield. Moreover, the bifunctional iron nanocomposite catalyst showed outstanding catalytic stability for successive recycles without appreciable loss of activity.

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

Novel synthesis method of benzene ring polysubstituted compound based on benzoyl formic acid

The invention relates to a novel synthesis method of a benzene ring polysubstituted compound based on benzoyl formic acid. According to the synthesis method, an acetophenone-based benzene ring polysubstituted compound is used as a raw material, a specific

Arylglyoxylic acid as well as preparation method and application thereof

The invention relates to arylglyoxylic acid as well as a preparation method and application thereof, and the method comprises the following steps: carrying out hydrolysis reaction on arylglyoxylonitrile oxime as shown in a formula (I) under the catalysis of an inorganic acid to obtain arylglyoxylic acid as shown in a formula (II). The arylglyoxylic acid prepared by the preparation method is high in yield, high in product purity, simple to operate, environment-friendly and pollution-free. The arylglyoxylic acid is used as a fine chemical synthesis intermediate.

Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities

Aberrant activation of p21-activated kinase 1 (PAK1) is associated with tumour progression, and PAK1 has been recognized as a promising target for anticancer drug discovery. However, the development of potent PAK1 inhibitors with satisfactory kinase selec

Cyclic tris-[5]helicenes with single and triple twisted M?bius topologies and M?bius aromaticity

A number of singly (180°) twisted, largely single-stranded and thus conformationally rather fragile, M?bius molecules have been synthesized within the last 15 years, which are aromatic with 4n electrons, thus violating the Hückel rule. Annulenes with sign

Umpolung Reactivity of Aldehydes toward Carbon Dioxide

Carbon dioxide is an intrinsically stable molecule. Therefore, its activation requires extra energy input in the form of reactive reagents and/or activated catalysts and, often, harsh reaction conditions. Reported here is a direct carboxylation reaction of aromatic aldehydes with carbon dioxide to afford α-keto acids as added-value products. In situ generation of a reactive cyanohydrin was the key to the successful carboxylation reaction under operationally mild reaction conditions (25–40 °C, 1 atm CO2). The resulting α-keto acids served as a platform for α-amino acid synthesis by reductive amination reactions, illustrating the chemical synthesis of essential bioactive molecules from carbon dioxide.

Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles in the Presence of a CONH Group

Stereospecific nucleophilic substitution was achieved for the first time with arylboronic acids as nucleophiles. This transition-metal-free coupling between chiral α-aryl-α-mesylated acetamides and arylboronic acids provided access to a series of chiral α,α-diaryl acetamides with excellent enantioselectivity and moderate to good yields. The CONH functionality proved to be crucial for bridging the reactants and promoting the reaction. Efficient syntheses of a cannabinoid CB1 receptor ligand, the antidepressant (S)-diclofensine, and a key chiral building block of the inhibitor implitapide were successfully accomplished by using this method.

Synthesis, β-catenin translocation capability and ALP activation activity of 7h-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives

Background: Osteoporosis (OP) is a common bone disease, most often diagnosed in post-menopausal women. The majority of OP treatments are focused on manipulation of the patient's hormone levels, therefore, they are associated with significant adverse effects. Objective: The study aimed to design, synthesize and evaluate the β-Catenin translocation capability and the alkaline phosphatase (ALP) activation activity of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives. Method: The styrene derivatives were synthesized as raw materials, followed by oxidation and condensation reactions, in which 6-aryl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one derivatives (1) were obtained. The 3,6-diaryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-ones (2) were obtained by a condensation reaction of compound 1 with substituted phenacyl chlorides in acetic acid. The target compounds 3,6-diaryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-ones (3a-3c) were prepared by compound 2 with substituted alkyl chloride by Williamson reaction. As to 6-benzyl-3-aryl-7H-thiazolo[3,2- b]-1,2,4-triazin-7-one derivatives as the target compounds, the benzaldehyde and acetylglycine used as raw materials, followed by Erlenmeyer-Pl?chl reaction, condensation reaction, hydrolysis reaction, condensation reaction, 6-benzyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one derivatives were obtained, and were converted to the target compounds 6-benzyl-3-(hydroxylaryl)-7Hthiazolo[ 3,2-b]-1,2,4-triazin-7-one derivatives (5a-5d) using reaction with substituted β-phenacyl chlorides. Finally, Williamson reaction were used to yield 6-benzyl-3-aryl-7H-thiazolo[3,2-b]- 1,2,4-triazin-7-ones as target compounds (6a-6e). The β-Catenin translocation capability and the ALP activation activity were tested, and the glycogen synthase kinase-3 (GSK-3) inhibition was simulated by molecular docking. Results: Fourteen 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were synthesized and characterized by mass spectra, proton NMR and infrared spectra, the β-Catenin translocation capability and the ALP activation activities of the target compounds were tested and calculated. The EC50 value of the ALP activation activity of 6-(4-chlorobenzyl)-3-{4-[(2-dimethylamino)-2- oxoethoxy]phenyl}-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one (6b) was 11.283 μM. The molecular docking results have showed that the target compounds would be GSK-3 inhibitors. Conclusion: Based on the results of the biological activity test, the target compounds have exhibited the β-Catenin translocation capability and the ALP activation activity.