1097263-60-9 Usage
Uses
Used in Pharmaceutical Industry:
BenzenesulfonaMide, N,N'-[1,2-ethanediylbis[oxy[5-(2-Methoxyphenoxy)[2,2'-bipyriMidine]-6,4-diyl]]]bis[4-(1,1-diMethylethyl)is used as an impurity in Bosentan, a mixed endothelin receptor antagonist, for the treatment of various medical conditions. The presence of BenzenesulfonaMide, N,N'-[1,2-ethanediylbis[oxy[5-(2-Methoxyphenoxy)[2,2'-bipyriMidine]-6,4-diyl]]]bis[4-(1,1-diMethylethyl)- in Bosentan is crucial for its therapeutic effects, as it contributes to the overall pharmacological profile of the drug.
As an impurity in Bosentan, BenzenesulfonaMide, N,N'-[1,2-ethanediylbis[oxy[5-(2-Methoxyphenoxy)[2,2'-bipyriMidine]-6,4-diyl]]]bis[4-(1,1-diMethylethyl)- plays a significant role in the drug's mechanism of action. It is believed to interact with the endothelin receptors, leading to the modulation of various physiological processes. This interaction is essential for the treatment of pulmonary arterial hypertension, a condition characterized by high blood pressure in the arteries that supply the lungs.
Furthermore, the presence of BenzenesulfonaMide, N,N'-[1,2-ethanediylbis[oxy[5-(2-Methoxyphenoxy)[2,2'-bipyriMidine]-6,4-diyl]]]bis[4-(1,1-diMethylethyl)in Bosentan may also contribute to the drug's efficacy in treating other medical conditions, such as digital ulcers and Raynaud's phenomenon, which are associated with systemic sclerosis.
Check Digit Verification of cas no
The CAS Registry Mumber 1097263-60-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,7,2,6 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1097263-60:
(9*1)+(8*0)+(7*9)+(6*7)+(5*2)+(4*6)+(3*3)+(2*6)+(1*0)=169
169 % 10 = 9
So 1097263-60-9 is a valid CAS Registry Number.
1097263-60-9Relevant academic research and scientific papers
Facile one-pot process for large-scale production of highly pure bosentan monohydrate, an endothelin receptor antagonist
Niphade, Navnath C.,Jagtap, Kunal M.,Gaikawad, Chandrashekhar T.,Jachak, Madhukar N.,Mathad, Vijayavitthal T.
, p. 1382 - 1387 (2012/01/11)
Described is an efficient, economic, and one-pot process for the production of highly pure bosentan (1), an endothelin receptor antagonist. The synthesis comprises the reaction of 4,6-dichloro-5-(2-methoxyphenoxy)-2,2′- bipyrimidine (2) with 4-tert-butylbenzenesulfonamide (3) and ethylene glycol (4) in acetonitrile in the presence of potassium carbonate to yield bosentan (1) in the same pot. The present work also describes a novel purification method for the removal of critical dimer impurity (7) and 6-hydroxy impurity (8) in 1 by preparation of bosentan ammonium salt (6) using inexpensive ammonium hydroxide. Upon purification, bosentan monohydrate (1) with an overall yield of 68% and HPLC purity of 99.90% was achieved.
