329923-15-1

Basic information

• Product Name: 4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine
• Synonyms: 4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine;4,6-Dihydroxy-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)pyrimidine;4,6-Dihydroxy-5-(o-methoxyphenoxy)-2,2bipyrimidine;4,6-Dihydroxy-5-(o-methoxyphenoxy)-2,2a€-bipyrimidine
• CAS NO: 329923-15-1
• Molecular Formula: C₁₅H₁₂N₄O₄
• Molecular Weight: 312.28018
• Product Categories: Aromatics;Bases & Related Reagents;Heterocycles;Nucleotides
• Mol File: 329923-15-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 133-135°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine(329923-15-1)
• EPA Substance Registry System: 4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine(329923-15-1)

Safety Data

• Hazardous Substances Data: 329923-15-1(Hazardous Substances Data)

Usage

Chemical Properties

Light-Green Powder

Uses

4,6-Dihydroxy-5-(o-methoxyphenoxy)-2,2’-bipyrimidine (cas# 329923-15-1) is a compound useful in organic synthesis.

Upstream product

• 150726-89-9 (2-methoxyphenoxy)-malonic acid dimethyl ester 
• 16879-48-4 2-pyrimidinecarboximidamide benzenesulphonate 
• 312613-82-4 2-amidinopyrimidine acetate 
• 20730-58-9 2-(2-Methoxyphenoxy)propanedioic acid diethyl ester 

Downstream Products

• 147536-97-8 bosentan 
• 150727-06-3 4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide 
• 1431507-36-6 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate 
• 174227-14-6 p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide 
• 1097263-60-9 N,N'-(6,6''-(ethane-1,2-diylbis(oxy))bis(5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-6,4-diyl))bis(4-(tert-butyl)benzenesulfonamide) 
• 157212-55-0 bosentan monohydrate 
• 403605-23-2 (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(naphthalen-1-yl)ethenesulfonamide 
• 403604-74-0 (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(naphthalen-2-yl)ethenesulfonamide 
• 218601-34-4 N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-3-phenylpropanesulfonamide 
• 403604-75-1 (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(pyridin-2-yl)ethenesulfonamide 
• 403604-76-2 (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(pyridin-3-yl)ethenesulfonamide 
• 403604-77-3 (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(pyridin-4-yl)ethenesulfonamide 
• 403604-78-4 (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-3-yl)ethenesulfonamide 
• 403604-79-5 (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(thiophen-2-yl)ethenesulfonamide 

Relevant articles and documents

ACID ADDITION SALTS OF BOSENTAN

The present invention relates to the stable acid addition salts of Bosentan that are useful for the purification of Bosentan base. In particular, the Bosentan acid addition salt is selected from Bosentan citrate and Bosentan tartrate.

PROCESSES FOR THE PREPARATION OF BOSENTAN AND ITS INTERMEDIATES THEREOF

The present invention relates to processes for the preparation of bosentan and compounds that can be used as structurally novel intermediates for the synthesis thereof, and a pharmaceutical composition of the same.

IMPROVED AND NOVEL PROCESS FOR THE PREPARATION OF BOSENTAN

The present invention relates to an improved and novel process for the preparation of bosentan compound of formula (1). The present invention also relates to a crystalline form of bosentan and its intermediates.