109729-06-8Relevant articles and documents
Synthesis of new 5-aryl tetrazoline from N-aceto hydrazide cyclic imides and study of biological activity
Al-Haidari, Akram S.,Al-Tamimi, Entesar O.
, p. 5647 - 5653 (2021/09/11)
The research resulted in the production of new tetrazoline derivatives. Firstly; the reaction of N-acetyl chloro cyclic imides with hydrazine hydrate to give compounds (1,2). Then, compounds (1,2) were reacted with different aromatic aldehydes to give Schiff bases (3-10). The compounds of N-( 2-chloro acetyl) cyclic imides were reacted with sodium azide to give N- (azido acetyl) cyclic imides (11,12). Finally, the reaction of the prepared Schiff bases compounds with azide compounds and cyclization to give 5-aryl tetrazoline on cyclic imides (13-20). The prepared compounds were characterized by FT-IR and some of them by 1H NMR, melting point, and were studied the effects of the preparing compounds on some strains of bacteria and fungi.
Design and synthesis of 2-(1, 3-dioxoisoindolin-2-yl)-N-(4-oxo-2- substitutedthiazolidin-3-yl) acetamide derivatives as potential anticonvulsant agents
Nikalje, Anna Pratima G.,Khan, Firoz Kalam,Ghodke, Mangesh
, p. 5448 - 5455 (2011/12/14)
A series of 2-(1,3-dioxoisoindolin-2-yl)-N-(4-oxo-2-substitutedthiazolidin- 3-yl) acetamide derivatives were designed and synthesized using appropriate synthetic route, keeping in view the structural requirement of pharmacophore and evaluated for anticonvulsant activity and CNS depressant activities in mice. The synthesized derivatives were examined in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (sc-PTZ) induced seizure and neurotoxicity screens and were also evaluated for behavioral activity. All the tested compounds showed protection against MES test indicative of their ability to inhibit the seizure spread.
