109745-88-2Relevant academic research and scientific papers
2-Trifluoroacetylthiopyridine-1-Hydroxybenzotriazole: A Powerful Reagent for Peptide Synthesis
Schmidt, Ulrich,Griesser, Helmut
, p. 1461 - 1462 (1993)
A mixture of trifluoroacetylthiopyridine, the sodium salt of 1-hydroxybenzotriazole, and an acylamino acid is able to acylate amino acid esters in high yields with minimal racemization and should, therefore, be useful for fragment condensation reactions i
Convergent synthesis of dolastatin 15 by solid phase coupling of an N- methylamino acid
Akaji, Kenichi,Hayashi, Yuzo,Kiso, Yoshiaki,Kuriyama, Naohiro
, p. 405 - 411 (2007/10/03)
Convergent synthesis of dolastatin 15 (1), a cytostatic depsipeptide isolated from the Indian Ocean sea hare, has been described. For construction of the backbone, a single-step condensation of peptide fragment 2 and pyrrolidone fragment 3 was successfull
Amino Acids and Peptides, 63. - Peptide Synthesis via N- or O-Activation of Amino Acids with 1,2-Dihydro-4,6-dimethyl-2-thioxo-3-pyridinecarbonitrile. - Synthesis of the 8-11 Tetrapeptide Sequence of Cyclosporin
Schmidt, Ulrich,Potzolli, Bernd
, p. 935 - 942 (2007/10/02)
Peptides and N-methyl peptides have been prepared in high yields and nearly free of racemisation via N-activation (Scheme 1) or O-activation (Scheme 2) of N-acylamino acids and N-acyl-N-methylamino acids, respectively, by 1,2-dihydro-4,6-dimethyl-2-thioxo
