109745-92-8Relevant academic research and scientific papers
SYNTHESIS OF TWO LINEAR OCTAPEPTIDE FRAGMENTS OF CYCLOSPORIN BY STEPWISE AND FRAGMENT CONDENSATION STRATEGIES
Galpin, I. J.,Mohammed, A. K. A.,Patel, A.,Priestley, G.
, p. 1763 - 1772 (2007/10/02)
The octapeptide Z-(Me)Leu-Val-(Me)Leu-Ala-D-Ala-(Me)Leu-(Me)Leu-(Me)Val-O(t-Bu) was prepared by stepwise elongation starting from H-(Me)Val-O(t-Bu).Diphenylphosphinic mixed anhydrides were preferentially used throughout as they gave high yields of optical
SOLUTION SYNTHESIS OF N-METHYLATED PEPTIDES BY THE DIPHENYL PHOSPHINIC MIXED ANHYDRIDE PROCEDURE
Galpin, I. J.,Mohammed, A. K.,Patel, A.
, p. 1685 - 1690 (2007/10/02)
A proton NMR method has been used to monitor racemisation during the coupling of N-methylated amino acids by the diphenylphosphinic mixed anhydride procedure.No racemisation was observed when urethane protection employed, but use of the benzoyl group led extensive racemisation.The reagent was subsequently used for the assembly of several extensively N-methylated peptides.
Amino Acids and Peptides, 63. - Peptide Synthesis via N- or O-Activation of Amino Acids with 1,2-Dihydro-4,6-dimethyl-2-thioxo-3-pyridinecarbonitrile. - Synthesis of the 8-11 Tetrapeptide Sequence of Cyclosporin
Schmidt, Ulrich,Potzolli, Bernd
, p. 935 - 942 (2007/10/02)
Peptides and N-methyl peptides have been prepared in high yields and nearly free of racemisation via N-activation (Scheme 1) or O-activation (Scheme 2) of N-acylamino acids and N-acyl-N-methylamino acids, respectively, by 1,2-dihydro-4,6-dimethyl-2-thioxo
